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https://journal.pda.org/content/67/3/214
May 01, 2013 · The objective of this work was to develop and evaluate a floating–pulsatile drug delivery of atenolol. The floating–pulsatile concept was applied to increase the gastric residence of the dosage form by having lag phase followed by a burst release.Author: Swati C. Jagdale, Monali S. Sali, Ajay L. Barhate, Bhanudas S. Kuchekar, Aniruddha R. Chabukswar
https://www.scholarsresearchlibrary.com/articles/formulation-and-evaluation-of-floating-pulsatile-drug-delivery-system-of-metoprolol-tartrate.pdf
floating pulsatile drug delivery. The gastroretentive pulsatile drug delivery system is useful for those drugs which have pH dependent solubility, poor bioavailability in gastrointestinal tract (GIT) and narrow absorption window.Author: Anuradha K. Salunkhe, Remeth J. Dias, Kailas K. Mali, Niranjan S. Mahajan, Vishwajeet S. Ghorpade
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178975/
A multiple unit oral floating drug delivery system of famotidine was developed to prolong gastric residence time, target stomach mucosa and increase drug bioavailability. Drug and polymer compatibility was studied by subjecting physical mixtures of drug …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065132/
Apr 14, 2014 · Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, primarily used for the treatment of hypertension, congestive heart failure, and heart attack. It belongs to BCS class III having a half-life of 12 hrs and 25% bioavailability. The purpose of the present work was to develop a press-coated, floating-pulsatile drug delivery system.
https://www.researchgate.net/publication/276247409_Formulation_and_evaluation_of_floating_pulsatile_drug_delivery_system_of_Metoprolol_tartrate
Floating drug delivery system enable prolonged and continuous input of the drug to the upper part of the gastro retentional tract and improve the bioavailability of medication that is ...
http://ijpsr.com/bft-article/formulation-and-in-vitro-evaluation-of-dry-coated-floating-pulsatile-drug-delivery-sysytem-of-enalapril-maleate/?view=fulltext
The floating- pulsatile concept can help to deliver the drug at definite place and time when symptoms of disease are more critical. The system consisted of three different parts, a core tablet, containing the active ingredient,...
https://www.academia.edu/32613713/FORMULATION_AND_EVALUATION_OF_FLOATING-_PULSATILE_DRUG_DELIVERY_SYSTEM_OF_ACECLOFENAC
The Chronopharmacotherapy the drug administration is synchronised with circadian rhythms Formulation development of Microspheres is more reliable formulation as compare to single type dosage formulation due to it avoids dose dumping, as per required
http://www.irjpbs.com/volumes/vol4/issue2/IRJPBS-4202.pdf
A combination of floating and pulsatile principles of drug delivery system would have the advantage that a drug can be released in upper GI tract after a defined time period of no drug release. A pulsatile drug delivery that can be administered at bed time but releases drug in early morning would be a promising chronotherapeutic system.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845978/
Purpose: A multiparticular floating-pulsatile drug delivery system was developed for time and site specific drug release of piroxicam. A blend of floating and pulsatile principles of drug delivery system would have the advantage that a drug can be released in the upper GI tract after a definite time period.Author: Maryam Maghsoodi, Elham Hemati, Bahram Qadermazi, Zahra Yari
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3548250/
Jul 01, 2011 · Pulsatile drug delivery systems (PDDS) have attracted attraction because of their multiple benefits over conventional dosage forms. They deliver the drug at the right time, at the right site of action and in the right amount, which provides more benefit than …Author: Deepika Jain, Richa Raturi, Vikas Jain, Praveen Bansal, Ranjit Singh
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