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https://iovs.arvojournals.org/article.aspx?articleid=2123954
To investigate the effect and safety of benzalkonium chloride on transscleral drug delivery in the rabbit after continuous intrascleral administration. methods. Betamethasone 21-phosphate (BP) aqueous solutions, with or without benzalkonium chloride (BAK), were continuously administered to albino rabbit sclera with an osmotic pump for 1 week.Author: Komei Okabe, Hideya Kimura, Junko Okabe, Aki Kato, Hideo Shimizu, Takashi Ueda, Shouichi Shimada, Yu...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6581159/
Jul 01, 2019 · Benzalkonium chloride (BAC) and dimethyldioctadecyl-ammonium bromide (DDAB), two common quaternary ammonium compounds, cause genotoxic effects in mammalian and plant cells at environmentally relevant concentrations.Author: Beatriz Merchel Piovesan Pereira, Ilias Tagkopoulos
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780662/
Mar 03, 2016 · The cytotoxic effects of preserved and preservative-free prostaglandin analogs on human corneal and conjunctival epithelium in vitro and the distribution of benzalkonium chloride homologs in ocular surface tissues in vivo.Author: Jie Shen, Marina Bejanian
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507684/
Most of these eye drops contain a preservative: the most commonly used is benzalkonium chloride (BAK), a quaternary ammonium salt composed of a mixture of benzododecinium C 21 H 38 N + (BAK C 12) and myristalkonium C 23 H 42 N + (BAK C 14) chlorides. BAK is a cationic surfactant and tensioactive compound, acting as a detergent for the lipid layer of the tear film as well as for the lipids …Author: Françoise Brignole-Baudouin, Nicolas Desbenoit, Gregory Hamm, Hong Liang, Jean-Pierre Both, Alain Br...
https://aem.asm.org/content/85/13/e00377-19
Jul 01, 2019 · Benzalkonium chlorides (BACs) are chemicals with widespread applications due to their broad-spectrum antimicrobial properties against bacteria, fungi, and viruses. This review provides an overview of the market for BACs, as well as regulatory measures and available data on safety, toxicity, and environmental contamination. We focus on the effect of frequent exposure of microbial …Author: Beatriz Merchel Piovesan Pereira, Ilias Tagkopoulos
https://www.sciencedirect.com/science/article/pii/S1773224718308803
Topical drug delivery to the posterior segment of the eye: The effect of benzalkonium chloride on topical dexamethasone penetration into the eye in vivo. Author links open overlay panel Sunna Johannsdottir a b Phatsawee Jansook c Einar Stefansson b d Iris Myrdal Kristinsdottir b Gudrun Marta Asgrimsdottir b Thorsteinn Loftsson a b.Author: Sunna Johannsdottir, Phatsawee Jansook, Einar Stefansson, Iris Myrdal Kristinsdottir, Gudrun Marta A...
https://www.drugs.com/breastfeeding/benzalkonium-chloride.html
Aug 02, 2019 · Benzalkonium Chloride Levels and Effects while Breastfeeding Summary of Use during Lactation Topical maternal application of benzalkonium chloride or benzethonium chloride or their presence as a preservative in pharmaceuticals would not be expected to cause any adverse effects in breastfed infants.
https://www.sciencedirect.com/topics/immunology-and-microbiology/benzalkonium-chloride
Pam Magee, in Side Effects of Drugs Annual, 2010. Comparative studies. Benzalkonium chloride is widely used as a preservative in eyedrops; in higher concentrations it is used as an antiseptic and disinfectant. In a randomized crossover study two concentrations of benzalkonium chloride, 0.1% and 0.4%, used as a sanitary wipe were compared with a 62% ethyl alcohol emollient gel for safety and ...
https://www.drugs.com/cdi/benzalkonium-chloride.html
If you have an allergy to benzalkonium chloride or any other part of benzalkonium chloride. If you are allergic to any drugs like this one, any other drugs, foods, or other substances. If you have a very bad burn or cut. If you have an animal bite or a deep puncture wound. If a large area needs to be treated.Brand names: Neosporin Wound Cleanser, CureChrome, HandClens 2 in 1, Merthiolate, Antimicrobial Cleanser
https://www.drugs.com/sfx/benzalkonium-chloride-topical-side-effects.html
Jan 05, 2020 · All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
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