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https://blog.nagendraningaraj.com/2019/09/29/drug-delivery-to-brain-tumours-challenges-and-progress-2/
This review will discuss the challenges of drug delivery across the blood–brain barrier/blood–brain tumour barrier to cancer cells, as well as progress made thus far. This will include a biochemical modulation strategy that transiently opens the barrier to increase anticancer drug delivery selectively to brain tumours.
https://www.tandfonline.com/doi/full/10.1517/17425247.3.4.499
This review will discuss the challenges of drug delivery across the blood–brain barrier/blood–brain tumour barrier to cancer cells, as well as progress made so far. This will include a biochemical modulation strategy that transiently opens the barrier to increase anticancer drug delivery selectively to …
https://www.researchgate.net/publication/6963257_Drug_delivery_to_brain_tumours_Challenges_and_progress
This review will discuss the challenges of drug delivery across the blood-brain barrier/blood-brain tumour barrier to cancer cells, as well as progress made so far. This will include a biochemical...
https://www.mdpi.com/journal/pharmaceutics/special_issues/drug_delivery_brain_tumor
CED enables delivery of conventional, nano-, bio-, gene, and even cellular therapies. This Special Issue provides a highlight of the most recent progress made to improve the efficacy of therapeutics delivered directly to brain tumors. Prof. Dr. Waldemar Debinski Prof. Dr. Michael Vogelbaum
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629063/
Apr 05, 2014 · Brain tumor-targeted drug delivery systems, which increase drug accumulation in the tumor region and reduce toxicity in normal brain and peripheral tissue, are a promising new approach to brain tumor treatments.Author: Xiaoli Wei, Xishan Chen, Man Ying, Weiyue Lu
https://www.sciencedirect.com/science/article/pii/S0168365918302682
The cellular transport mechanism of drug transport from the nasal cavity to the brain is illustrated schematically in Fig. 4. In general, the nose to brain drug delivery involves the transfer of drug mainly from respiratory epithelium and olfactory region through trigeminal nerve and olfactory nerve cells.Author: Mukta Agrawal, Swarnlata Saraf, Shailendra Saraf, Sophia G. Antimisiaris, Mahavir Bhupal Chougule, S...
https://www.sciencedirect.com/science/article/abs/pii/S0168365918302682
Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs. ... we want to drag the attention of the researchers working in this field towards the challenges and hurdles of practical applicability IN delivery of anti-AD drugs.Author: Mukta Agrawal, Swarnlata Saraf, Shailendra Saraf, Sophia G. Antimisiaris, Mahavir Bhupal Chougule, S...
https://www.nature.com/articles/s41467-018-03705-y
Apr 12, 2018 · Targeted delivery approaches for cancer therapeutics have shown a steep rise over the past few decades. However, compared to the plethora of successful pre-clinical studies, only 15 passively targeted nanocarriers (NCs) have been approved for clinical use and none of the actively targeted NCs have advanced past clinical trials.Author: Daniel Rosenblum, Nitin Joshi, Nitin Joshi, Wei Tao, Jeffrey M. Karp, Jeffrey M. Karp, Dan Peer
https://www.nature.com/articles/nrd.2015.21
Jan 22, 2016 · Research in the past few decades has revealed that the BBB is not only a substantial barrier for drug delivery to the CNS but also a complex, dynamic interface that adapts to the needs of the CNS, responds to physiological changes, and is affected by and can even promote disease.Author: William A. Banks
https://www.sciencedirect.com/science/article/pii/S2211383516301186
RGD also is a peptide that is widely used in brain tumor targeting delivery because its target, integrin receptor αvβ3, is overexpressed on brain tumor cells and especially on brain tumor neovessels 147. In vitro, RGD modification elevated the uptake by brain tumor …
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