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https://www.ncbi.nlm.nih.gov/pubmed/12529929
1. Vascul Pharmacol. 2002 Jun;38(6):349-54. Drug delivery to brain via the blood-brain barrier. Scherrmann JM(1). Author information: (1)INSERM U26, Hôpital Fernand Widal, 200 rue du Faubourg Saint-Denis, 75475, Paris, France. [email protected] 1. Many neurodegenerative diseases, cancer and infections of the brain become more prevalent as …Author: J.-M Scherrmann
https://www.drugtargetreview.com/news/36234/deliver-blood-brain/
Oct 19, 2018 · Drug delivery through the blood-brain barrier has shown to be difficult to overcome, but researchers may have discovered a method to overcome this issue… Research on the delivery of therapeutics to the brain could have implications for the treatment of a wide range of diseases, such as Alzheimer’s, ALS, brain cancer and Parkinson’s.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494002/
Aug 29, 2012 · Drug transport across the blood–brain barrier. William M Pardridge ... Drug delivery to the brain via the CSF is limited by the slow diffusion of drug ... Pardridge WM. Epidermal growth factor radiopharmaceuticals: 111In chelation, conjugation to a blood-brain barrier delivery vector via a biotin-polyethylene linker, pharmacokinetics, and in ...Author: William M Pardridge
https://www.sciencedirect.com/science/article/pii/S1537189102002021
1. Introduction. The brain is probably one of the least accessible organs for the delivery of active pharmacological compounds. Despite its relatively high blood flow, there are two physiological barriers separating the brain from its blood supply and they control the entry and exit of endogenous and exogenous compounds.Author: J.-M Scherrmann
https://pubs.acs.org/doi/abs/10.1021/acsnano.6b04268
We developed a green method for blood–brain barrier (BBB)-penetrating albumin nanoparticle synthesis, with the capacity to coencapsulate different drugs and no need for cross-linkers. The hydrophobic drugs (i.e., paclitaxel and fenretinide) yield synergistic effects to induce albumin self-assembly, forming dual drug-loaded nanoparticles.Author: Tingting Lin, Tingting Lin, Pengfei Zhao, Yifan Jiang, Yisi Tang, Hongyue Jin, Zhenzhen Pan, Huining...
https://www.researchgate.net/publication/10948816_Drug_delivery_to_brain_via_the_blood-brain_barrier
Drug delivery and clearance in the central nervous system (CNS) are restricted and regulated by the blood-brain barrier (BBB), the blood-cerebrospinal fluid barrier (BCSFB), and the blood ...
https://www.sciencedirect.com/science/article/pii/S0169409X11002900
5.2. Transport system-mediated drug delivery across the blood–brain barrier. The combination of endogenous transport systems present in the BBB and macromolecular conjugates or surface enhanced nano-particulate delivery systems such as liposomes, nanoparticles and supermolecular complexes has been utilised to access the brain.Author: Yan Chen, Lihong Liu
https://www.researchgate.net/publication/12106003_Drug_delivery_via_the_blood-brain_barrier
Drug delivery via the blood-brain barrier. ... Uptake via the paracellular pathway, on the other hand, is attractive route for the absorption of high molecular weight and largesized drugs ...Author: Robert H Edwards
https://www.pharmafocusasia.com/articles/blood-brain-barrier-and-cns-drug-delivery
Blood-Brain Barrier and CNS Drug Delivery Parvin Zakeri-Milani , Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran. The central nervous system is protected by barriers which control the passage of various chemical substances and microscopic objects, thereby regulating brain homeostasis.
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