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https://www.sciencedirect.com/science/article/pii/S0165017301000832
Drug delivery to damaged brain 3.1. Therapeutic targets in stroke and trauma. 3.2. Blood–brain barrier in damaged brain. 3.3. Reductions in cerebral blood flow. In considering intravascular delivery of therapeutic drugs,... 3.4. Edema and interstitial pressure. A prominent feature of acute brain ...Author: Eng H. Lo, Aneesh B. Singhal, Vladimir P. Torchilin, N.Joan Abbott
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281266/
Drug Delivery to the Hypoxic/Ischemic Brain The ability of drugs such as statins to be effective neurotherapeutics following cerebral hypoxia/ischemia requires efficient and precise CNS delivery.Author: Brandon J. Thompson, Patrick T. Ronaldson
https://www.mdpi.com/journal/pharmaceutics/special_issues/drug_delivery_to_the_brain
The blood–brain barrier (BBB) and blood–cerebrospinal fluid (BCSF) barriers are critical determinants of CNS homeostasis. Additionally, the BBB and BCSF barriers are formidable obstacles to effective drug delivery to the brain.
https://www.researchgate.net/publication/223255953_Drug_delivery_to_damaged_brain
Drug delivery to the brain poses unique challenges. Specialized anatomic and physiological features of the cerebrovasculature and cerebral tissue fluids result in barriers which significantly ...
http://jpet.aspetjournals.org/content/370/3/593
Sep 01, 2019 · Olanzapine, when loaded onto PLGA nanoparticles, resulted in delivery to the brain that was 10 times more efficient than nose-to-brain delivery with olanzapine solution, resulting in a C max of 0.049% of the dose and a C max of 0.0045% of the dose with the nanoparticle and solution formulations, respectively (Seju et al., 2011).Author: Zian Wang, Guojun Xiong, Wai Chun Tsang, Andreas G. Schätzlein, Ijeoma F. Uchegbu
https://www.medicalnewstoday.com/articles/324410
Scientists have shown how a drug cocktail of four compounds can convert glia, or support cells, next to damaged neurons into new working neurons. Newsletter Simple drug formula regenerates brain cells
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