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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4289909/
The major challenge faced by today’s pharmacologist and formulation scientist is ocular drug delivery. Topical eye drop is the most convenient and patient compliant route of drug administration, especially for the treatment of anterior segment diseases.Author: Ashaben Patel, Kishore Cholkar, Vibhuti Agrahari, Ashim K Mitra
https://www.sciencedirect.com/science/article/pii/S1569259005100123
Drug Delivery to the Eye I. Introduction. Ophthalmic drug delivery is one of the most challenging tasks facing scientists in... II. Structure and Function of the Eye. The eye is a spherical structure with a wall consisting... III. Ocular Fluid Dynamics. Aqueous humor is derived from plasma within ...Author: Ashim K. Mitra, Banmeet S. Anand, Sridhar Duvvuri
https://www.glaucoma.org/treatment/new-medication-delivery-systems-for-glaucoma.php
The basic idea of drug delivery systems for glaucoma is to apply, insert, or inject medication to the eye that will release over weeks or months. Various delivery approaches are being developed that can be categorized as: on the eye, in the eye, and around the eye.
https://pharm.ucsf.edu/desai/research/ocular-drug-delivery
A drug delivery device capable of sustained release of biological therapeutics over several months can maintain effective therapeutic concentrations and reduce the number of injections, significantly improving ocular therapies. One attractive platform for continuous delivery of antibody-based therapeutics is the use of nanoporous materials.
https://eye.hms.harvard.edu/topic/drug-delivery-medical-devices
Residing under the tears, the cornea is the primary gateway into the eye for many topical ophthalmic drugs. We hypothesized that a drug-eluting contact lens that rests on the cornea would therefore be well-suited for delivering drugs to the eye including the retina.
https://www.sciencedirect.com/science/article/pii/S1359644610008421
Drug delivery to the posterior segment of the eye is therefore compounded by the increasing number of new therapeutic entities (e.g. oligonucleotides, aptamers and antibodies) and the need for chronic therapy. Currently, the intravitreal route is widely used to deliver therapeutic entities to the retina.Author: Thilini Rasika Thrimawithana, Simon Young, Craig Robert Bunt, Colin Green, Raid Ghassan Alany
https://www.researchgate.net/publication/227415002_Drug_delivery_to_eye_Special_reference_to_nanoparticle
Effective drug delivery to the eye is a challenging proposition for the pharmaceutical scientist. Eye drops have been globally accepted as a formulation for anterior segment applications.
http://www.authorstream.com/Presentation/deepscpn-2284224-ocular-drug-delivery-system/
Oct 03, 2014 · ROLE OF POLYMERS IN OCULAR DRUG DELIVERY : To increase viscosity of solution ultimately reduce solution drainage. e.g. PVP, PVA. By increasing viscosity bioavailability is also increased. Prolong residence time with an extended duration of action. Optimal viscosity of ocular drug delivery system is 12-15 cps.
https://www.ondrugdelivery.com/sustained-drug-delivery-posterior-segments-eye/
Drug delivery to the posterior segment of the eye is most efficiently achieved by local, ocular routes of administration, which includes intravitreal, subretinal, suprachoroidal and periocular injections. 6,7 Intravitreal injections and implants deliver drugs effectively to the retina and the choroid.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895432/
May 01, 2010 · Designing a drug delivery system to target a particular tissue of the eye has become a major challenge for scientists in the field. The eye can be …Author: Ripal Gaudana, Hari Krishna Ananthula, Ashwin Parenky, Ashim K. Mitra
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