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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998643/
Many approaches to overcome, circumvent, disrupt, or manipulate the BBB to enhance delivery of drugs to brain tumors have been devised and are in active investi gation. These approaches include high-dose intravenous chemotherapy, intra-arterial drug delivery, local drug delivery via implanted polymers or catheters, BBB dis ruption, and biochemical modulation of drugs.Author: Jaishri Blakeley
https://www.mdpi.com/journal/pharmaceutics/special_issues/drug_delivery_brain_tumor
The most widely used method for direct brain delivery is convection-enhanced delivery (CED), whereby specially designed catheters are introduced into target tissue and the infusate is delivered slowly over a prolonged period of time. CED enables delivery of conventional, nano-, bio-, …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752842/
Another advantage of this approach is that imaging agents can be encapsulated within the particle along with the anticancer drug allowing non invasive monitoring of drug delivery to brain tumors . Colloidal systems, such as liposomes and nanoparticles, have shown promising features as drug carriers to target brain tumors after intravenous administration, and this technology is currently in early preclinical …Author: Valentino Laquintana, Adriana Trapani, Nunzio Denora, Fan Wang, James M Gallo, Giuseppe Trapani
https://link.springer.com/article/10.1007/s11910-008-0036-8
May 29, 2008 · Many approaches to overcome, circumvent, disrupt, or manipulate the BBB to enhance delivery of drugs to brain tumors have been devised and are in active investigation. These approaches include high-dose intravenous chemotherapy, intra-arterial drug delivery, local drug delivery via implanted polymers or catheters, BBB disruption, and biochemical modulation of drugs.Author: Jaishri Blakeley
https://www.sciencedirect.com/science/article/pii/S0092824096000250
Vasoactive compounds are DRUG DELIVERY TO BRAIN TUMORS 1049 molecules used to selectively increase the permeability of the BTB while leaving the BBB in …Author: Wynn L. Walker, Julian Cook
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629063/
Apr 05, 2014 · The “systematic targeted drug delivery” or “whole-process targeting” is recognized as an effective brain tumor targeted drug delivery strategy which considers all the possible targets including barriers, microenvironment and cancer cells.Author: Xiaoli Wei, Xishan Chen, Man Ying, Weiyue Lu
https://www.nature.com/articles/s41467-019-13198-y
Nov 15, 2019 · Conventional chemotherapies through the intravenous delivery are oftentimes unsuccesful since the blood–brain barrier blocks delivery of drugs to brain tumors 4.Author: Jongha Lee, Hye Rim Cho, Gi Doo Cha, Hyunseon Seo, Hyunseon Seo, Seunghyun Lee, Chul Kee Park, Jin W...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936295/
Feb 12, 2014 · 5.2 FUS-enhanced brain tumor drug delivery using BCNU-loaded MBs. While MB-FUS-mediated BBB disruption enhances the delivery of BCNU to brain tumors, the short half-life of BCNU (20-50 min in vitro and less than 15 min in vivo) still intrinsically limits its efficacy after systemic application 101, 102.Author: Hao-Li Liu, Ching-Hsiang Fan, Chien-Yu Ting, Chih-Kuang Yeh
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3272876/
Aug 10, 2011 · One such area is targeted drug delivery to solid tumors. The clinically significant impact of targeted drug delivery lies in the ability to specifically target a drug or drug carrier to minimize drug-originated systemic toxic effects.Author: You Han Bae, Kinam Park
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