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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130907/
Jan 12, 2011 · Lysosomes are probably the most important barrier to genetic material delivery to different cell types, including neurons. Following endocytosis, the vacuoles become accessible to early endosomes, before fusing with late endosomes and, finally, with lysosomes to …Author: Francisco C. Pérez-Martínez, Javier Guerra, Inmaculada Posadas, Inmaculada Posadas, Valentín Ceña, V...
https://www.ncbi.nlm.nih.gov/pubmed/21225319
However, one of the main problems for the use of non-viral gene vectors for neuronal transfection is their low efficiency when compared with viral vectors. Transgene expression, or siRNA delivery mediated by non-viral vectors, is the result of multiple processes related to cellular membrane crossing, intracellular traffic, and/or nuclear delivery of the genetic material cargo.Author: Francisco C. Pérez-Martínez, Javier Guerra, Inmaculada Posadas, Inmaculada Posadas, Valentín Ceña, V...
https://link.springer.com/article/10.1007/s11095-010-0364-7
Jan 12, 2011 · When NPs are used as non-viral delivery systems, the main role of the cells involved in phagocytosis in the CNS is to clear NPs from the brain. This internalization pathway therefore plays a critical physiological role by reducing the toxicity and effectiveness of most NPs used for drug or genetic material delivery.Author: Francisco C. Pérez-Martínez, Javier Guerra, Inmaculada Posadas, Inmaculada Posadas, Valentín Ceña, V...
https://link.springer.com/content/pdf/10.1007%2Fs11095-010-0364-7.pdf
siRNA delivery mediated by non-viral vectors, is the result of multiple processes related to cellular membrane crossing, intracellular traffic, and/or nuclear delivery of the genetic material cargo. This review will deal with the barriers that different nanoparticles (cationic lipids, polyethyleneimine, den-Author: Francisco C. Pérez-Martínez, Javier Guerra, Inmaculada Posadas, Inmaculada Posadas, Valentín Ceña, V...
https://www.researchgate.net/publication/49746137_Barriers_to_Non-Viral_Vector-Mediated_Gene_Delivery_in_the_Nervous_System
Barriers to Non-Viral Vector-Mediated Gene Delivery in the Nervous System Article · Literature Review (PDF Available) in Pharmaceutical Research 28(8):1843-58 · August 2011 with 201 Reads
http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.290.4914
nervous system non-viral vector-mediated gene delivery expert review barrier viral vector neuronal transfection target cell blood-brain barrier safety concern cell line transfection dna transfection main problem abstract efficient method non-viral vector nuclear delivery intracellular traffic cationic lipid low efficiency vector preparation primary neuron multiple process viral transfection nuclear membrane non-viral gene vector …
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