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https://emisphere.com/barriers/
Emisphere's Eligen ® Technology overcomes major obstacles to effective oral delivery including: Degradation. The high acid content and enzymes of the digestive tract can degrade some drugs, particularly protein and peptide drugs, before they are absorbed into the bloodstream.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/oral-drug-delivery
Barriers to oral drug delivery include solubility and dissolution, absorption, presystemic metabolism, and excretion. For drugs whose targets are easily accessible, the portion of drugs reaching systemic circulation after overcoming all of these barriers is considered bioavailable.
https://onlinelibrary.wiley.com/doi/10.1002/0471475734.ch2
Mar 11, 2005 · Physiological, Biochemical, and Chemical Barriers to Oral Drug Delivery Anna Maria Calcagno Department of Pharmaceutical Chemistry, The …Author: Anna Maria Calcagno, Teruna J. Siahaan
https://link.springer.com/chapter/10.1007/978-1-4612-5186-6_5
During the last ten to twenty years there have been major changes in the drug discovery process. As a result of a greater understanding of the pathology and biochemical defects responsible for... Gastrointestinal Barrier to Oral Drug Delivery SpringerLinkAuthor: Colin R. Gardner
https://onlinelibrary.wiley.com/doi/full/10.1111/bcpt.12342
Oct 27, 2014 · Mucus is thus a highly complex gel barrier to drug delivery. Current knowledge of mucus characteristics and barrier properties, as achieved by state‐of‐the‐art methodologies, is the topic of this MiniReview emphasizing the gastrointestinal mucus and an overall focus on oral drug delivery.Author: Marie Boegh, Hanne Mørck Nielsen
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225504/
Natural barriers of the human body and their implications for oral drug delivery via nanocarriers. The major obstacle for oral drug delivery via nanocarriers is the fact that the nanocarrier needs to cross several natural barriers of the human body before the incorporated drug can reach the target cell.Author: Jonas Reinholz, Katharina Landfester, Volker Mailänder
http://www.onecentralpress.com/wp-content/uploads/2016/02/NDD-8-Chapter-3.pdf
effective oral drug delivery. Physiological barriers to the oral delivery of therapeutics When it comes to therapeutics, a big distinction must be done between small molecule therapeutics and biopharmaceuticals. Small molecule drugs are those with low molecular weight (e.g. < 800 Da) produced by chemical synthesis or present as naturally ...
https://www.sciencedirect.com/science/article/pii/S0169409X11003036
Another important consideration for oral drug delivery is that the barrier properties of mucus are altered in disease states. Despite the highly protective properties of GI mucus, breaches do occur. On a daily basis, the GI tract is confronted with the formidable task of allowing transfer and uptake of nutrients and fluids, while being confronted with potentially harmful substances and pathogenic bacteria.Author: Laura M. Ensign, Laura M. Ensign, Richard Cone, Richard Cone, Justin Hanes
https://www.slideshare.net/PrachiJoshi8/barriers-encountered-in-drug-delivery
Jan 26, 2015 · • LIPOSOMES: Liposomes are small vesicles that are composed of unilamellar or multilamellar phospholipids bilayers surrounded by aqueous compartments. PRODRUG: The prodrug are used to overcome various barriers which can hinder drug delivery, including solubility.
https://pharm.ucsf.edu/desai/research/oral-drug-delivery
Oral Drug Delivery Oral delivery is the preferred route for drug administration because it is less invasive than other traditional routes. The pharmaceutical and biotechnology industries are continuously developing peptides, proteins, biopolymer, and macromolecular drugs …
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