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https://www.herontx.com/our-technologies
Our Technologies Biochronomer ® Technology. Our proprietary Biochronomer drug delivery technology can deliver therapeutic levels of otherwise shorter-acting pharmacological agents over a period of days to weeks with a single subcutaneous injection or application.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863535/
Dec 09, 2014 · POEs are a family of bioerodible polymers that contain an orthoester linkage, and the use of these polymer systems is specifically designed for sustained release drug delivery applications. 13 Biochronomer™ is a fourth-generation POE proprietary technology developed by Heron Therapeutics, Inc. (formerly AP Pharma, Inc.; Redwood City, CA, USA ...Author: Thomas Ottoboni, Mark S Gelder, Erin O’Boyle
http://www.pharmanet.com.br/pdf/drugdelivery.pdf
a new drug delivery system can signifi-cantly improve its performance in terms of efficacy, safety, and improved patient compliance. The need for delivering drugs to patients efficiently and with fewer side effects has prompted pharmaceutical com-panies to engage in the development of new drug delivery systems.Today,drug delivery
https://www.biospace.com/article/releases/fda-denies-approval-of-a-p-pharma-inc-nausea-drug-/
Mar 19, 2010 · APF530 contains the 5-HT3 antagonist, granisetron, formulated in the Company's proprietary Biochronomer(TM) drug delivery system, which allows therapeutic drug levels to be maintained for five days with a single subcutaneous injection.
https://www.slideshare.net/DrReshmiSameeth/newer-drug-delivery-systems-57381833
Jan 22, 2016 · Newer Drug Delivery Systems 1. NEWER DRUG DELIVERY SYSTEMS Dr.Reshmi.T.R, 2. Definition Therapeutic systems that incorporate drugs in a dosage form that releases the medication • at a predetermined rate • over an extended period of …
https://www.researchgate.net/publication/7471368_Biochronomer_technology
The drug release rate from these formulations can be adjusted to provide delivery over a period of days to weeks by controlling the composition and molecular weight of the TEG-POE as well as the ...
https://www.cmocro.com/news_detail/A.P.+Pharma+Files+First+Investigational+New+Drug+Application/13330/index.html
About the Biochronomer System The Biochronomer polymer system is a family of bioerodible polymers specifically designed for drug delivery. The entire family of polymers is a versatile delivery platform, which can deliver drugs over a wide range of time periods.
https://www.thermofisher.com/uk/en/home/industrial/pharma-biopharma/drug-discovery-development/drug-delivery-systems.html
Subcutaneous, solid implants are an emerging drug delivery system with special manufacturing needs when going from powder to ready-for-packaging product. In order to deliver the active pharmaceutical ingredient (API) safely and with a constant dissolution rate, a very homogeneous product with extremely tight tolerances in geometry is required.
https://herontherapeutics.gcs-web.com/news-releases/news-release-details/ap-pharma-reports-fourth-quarter-and-year-end-2001-results
"In particular the new Biochronomer(TM) drug delivery system, discovered and developed by A.P. Pharma, was characterized in over 60 in vivo and in vitro studies. Moreover, the first product incorporating the Biochronomer technology, APF112 for the treatment of post-surgical pain, entered the clinic early in 2002." Fourth Quarter Highlights:
https://www.dovepress.com/biochronomertrade-technology-and-the-development-of-apf530-a-sustained-peer-reviewed-article-JEP
Biochronomer™ technology and the development of APF530, a sustained release formulation of granisetron Thomas Ottoboni,1 Mark S Gelder,1 Erin O’Boyle2 1Heron Therapeutics, Inc., Redwood City, CA, USA; 2FibroGen, Inc., San Francisco, CA, USA Abstract: Granisetron and other 5-hydroxytryptamine type 3 (5-HT3) receptor antagonists are first-line agents for preventing chemotherapy-induced ...
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