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https://www.ncbi.nlm.nih.gov/pubmed/12532370
Finally, nuclear uptake has been demonstrated to be a significant barrier to gene delivery. In this review, we outline in greater detail the various processes involved in each step and describe various formulation variables that have been explored to overcome these delivery barriers to nonviral gene delivery.Author: Christopher M. Wiethoff, C.Russell Middaugh
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130907/
Jan 12, 2011 · The use of non-viral vectors has been proposed to overcome the aforementioned drawbacks of their viral counterparts. However, one of the main problems of such non-viral gene vectors is their low transfection efficiency compared with viral vectors (2, 3). Transgene expression, or siRNA delivery mediated by non-viral vectors, is the result of ...Author: Francisco C. Pérez-Martínez, Javier Guerra, Inmaculada Posadas, Inmaculada Posadas, Valentín Ceña, V...
https://www.intechopen.com/books/novel-gene-therapy-approaches/extracellular-and-intracellular-barriers-to-non-viral-gene-transfer
To maximize non-viral gene delivery, levels of expression must be improved. Unfortunately, many extracellular and intracellular barriers (including the extracellular environment, immune scavengers, the cell membrane, endosomal escape, the cytoskeletal network and the nuclear membrane) preclude efficient gene transfer.Author: Lynn F. Gottfried, David A. Dean
https://www.sciencedirect.com/science/article/pii/S1748013218300793
Biological barriers for non-viral gene therapy are typically divided into two categories: extracellular (EC) and intracellular (IC) barriers. In short, EC barriers need to be overcome prior to reaching the target cell. In Fig. 1, the barriers after systemic administration are shown. These include endo- and exonuclease activity in the blood ...Author: Lotte M.P. Vermeulen, Toon Brans, Stefaan C. De Smedt, Katrien Remaut, Kevin Braeckmans
https://link.springer.com/article/10.1007/s11095-010-0364-7
Jan 12, 2011 · The use of non-viral vectors has been proposed to overcome the aforementioned drawbacks of their viral counterparts. However, one of the main problems of such non-viral gene vectors is their low transfection efficiency compared with viral vectors (2, 3). Transgene expression, or siRNA delivery mediated by non-viral vectors, is the result of ...Author: Francisco C. Pérez-Martínez, Javier Guerra, Inmaculada Posadas, Inmaculada Posadas, Valentín Ceña, V...
https://www.sciencedirect.com/science/article/pii/S2468451118300254
Non-viral gene delivery via the oral route is a promising strategy for improving outcomes of DNA vaccination and gene therapy applications. Unlike traditional parenteral administration routes, the oral route is a non-invasive approach that lends itself to high patient compliance and ease of dosing.Author: Eric Farris, Kari Heck, Anna T. Lampe, Deborah M. Brown, Amanda E. Ramer-Tait, Angela K. Pannier
https://www.slideshare.net/Aparajitha_Anne/gene-delivery-system
May 19, 2012 · Inorganic Nanoparticles:It one of the non-viral gene delivery system where we use gold .silicaand iron oxide and calcium phosphate some of the benefits are storagestability, low manufacturing cost and often time, low immunogenicity. 30.
https://pubs.acs.org/doi/10.1021/mp400467x
Oct 04, 2013 · A key end goal of gene delivery research is to develop clinically relevant vectors that can be used to combat elusive diseases such as AIDS. Despite promising engineering strategies, efficiency and ultimately gene modulation efficacy of nonviral vectors have been hindered by numerous in vitro and in vivo barriers that have resulted in subviral performance. In this perspective, we concentrate ...Author: Charles H. Jones, Chih-Kuang Chen, Anitha Ravikrishnan, Snehal Rane, Blaine A. Pfeifer
https://www.researchgate.net/publication/11269723_Intracellular_Barriers_to_Non-Viral_Gene_Transfer
Non-viral vector mediated gene transfer, compared to viral vector mediated one, is a promising tool for the safe delivery of therapeutic DNA in genetic and acquired human diseases.
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