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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821413/
For the most part, targeted delivery using aptamers have been performed using aptamers selected against receptors known to be internalized, and a variety of different cargoes have now been successfully delivery both in vitro as well as in vivo (Figure 2).
https://www.tandfonline.com/doi/pdf/10.4161/rna.6.3.8808
Cell targeting and delivery with nucleic acid aptamers aptamers that target specific proteins and/or cell surface receptors. A number of these aptamers have been adapted for diagnostic and imaging purposes. For example, Borbas et al. and Hicke et al. both used radiolabeled forms of anti-MUC-1 …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
The perfect target for aptamer-mediated delivery is one that is highly expressed on all target cells, is efficiently internalized, and is not expressed on the surface of non-target cells. Although a perfect target may not exist, several aptamers against excellent targets have been identified.Author: Partha Ray, Rebekah R. White
https://www.intechopen.com/online-first/aptamers-for-targeted-delivery-current-challenges-and-future-opportunities
Aptamers are synthetic ssDNA/RNA molecules that are emerging as novel tools for the development of therapeutics, especially for targeted delivery. Aptamers are comparable to monoclonal antibodies, which are well-established therapeutic molecules, in terms of specificity and affinity to their target.Author: Chetan Chandola, Muniasamy Neerathilingam
https://www.tandfonline.com/doi/abs/10.4161/rna.6.3.8808
In recent years, advances in aptamer techniques have enabled the use of aptamers as small molecule inhibitors, diagnostic tools and even therapeutics. Aptamers are now being employed in novel applications. We review, herein, some of the recent and exciting applications of aptamers in cell-specific recognition and delivery.Author: Amy C. Yan, Matthew Levy
https://www.researchgate.net/publication/24442707_Aptamers_and_aptamer_targeted_delivery
Areas covered: This review covers brief overview of aptamers and dendrimers, with specific focus on recent progresses of aptamer-dendrimer (Apt-D) bioconjugate in areas of targeted drug delivery ...
https://www.sciencedirect.com/science/article/pii/S1525001616307286
Aptamer-targeted Antigen Delivery. Effective therapeutic vaccines often require activation of T cell-mediated immunity. Robust T cell activation, including CD8 T cell responses, can be achieved using antibodies or antibody fragments to direct antigens of interest to professional antigen presenting cells.Author: Brian C Wengerter, Joseph A Katakowski, Jacob M Rosenberg, Jacob M Rosenberg, Chae Gyu Park, Chae Gy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4089008/
May 06, 2014 · Aptamers that are specific for surface receptors have previously been used for targeted delivery of molecular cargoes, including small molecule drugs, 27 toxins and other proteins, 28,29 as well as nanoparticles. 30 And while aptamers have been developed to target some immunologically relevant receptors and modulate immune responses, 9,31,32 aptamers have not yet been used for targeted delivery …Author: Brian C Wengerter, Joseph A Katakowski, Jacob M Rosenberg, Jacob M Rosenberg, Chae Gyu Park, Chae Gy...
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