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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821413/
For example, Xiao et al. demonstrated that an aptamer previously selected naively against T-cells bound to protein kinase 7 and could be internalized. 31 They subsequently adapted this aptamer for targeted delivery of the drug doxorubicin using an acid labile drug conjugate. 50
https://www.tandfonline.com/doi/pdf/10.4161/rna.6.3.8808
Cell targeting and delivery with nucleic acid aptamers aptamers that target specific proteins and/or cell surface receptors. A number of these aptamers have been adapted for diagnostic
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
Keywords: Systemic Evolution of Ligands by Exponential Enrichment (SELEX), aptamers, targeted drug delivery. 1. Introduction ... In one of the first examples of aptamer-mediated delivery, Chu et al. realized that the anti-PSMA aptamer could be employed to deliver this toxic payload into prostate cancer cells that express PSMA. Gelonin was ...Author: Partha Ray, Rebekah R. White
https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(16)30728-6
Jul 01, 2014 · Aptamer-targeted Antigen Delivery Effective therapeutic vaccines often require activation of T cell-mediated immunity. Robust T cell activation, including CD8 T cell responses, can be achieved using antibodies or antibody fragments to direct antigens of interest to professional antigen presenting cells.Author: Brian C Wengerter, Joseph A Katakowski, Jacob M Rosenberg, Jacob M Rosenberg, Chae Gyu Park, Chae Gy...
https://www.dovepress.com/aptamer-drug-conjugate-targeted-delivery-of-doxorubicin-in-a-her3-apta-peer-reviewed-fulltext-article-IJN
This is a proof-of-concept study testing aptamer-drug conjugate (ApDC) targeted delivery systems for chemotherapeutic drugs.Methods: Aptamer library targeting human epidermal growth factor receptor 3 (HER3) was screened and affinity was determined by enzyme-linked immunosorbent assay.Author: Xiao-qian Dou, Hua Wang, Jing Zhang, Fang Wang, Gui-li Xu, Cheng-cheng Xu, Huan-hua Xu, Shen-si Xian...
https://www.nature.com/articles/nrd.2016.199
Nov 03, 2016 · In addition, many aptamers are internalized upon binding to cellular receptors, making them useful targeted delivery agents for small interfering RNAs …Author: Jiehua Zhou, John Rossi
https://www.slideshare.net/AnuragPandey60/aptamers-based-drug-delivery-93903621
Apr 15, 2018 · Aptamers for Targeted Drug Delivery, Partha Ray and Rebekah R. White & Department of Surgery, Duke University Medical Center, DUMC Box 103035, Durham, NC 27710, USA 2. Progress and Challenges in Developing Aptamer-Functionalized Targeted Drug Delivery Systems, Feng Jiang, International Journal of Molecular Sciences ISSN 1422-0067 3.
https://www.slideshare.net/SurenderBansal/aptamer-as-therapeutic
Apr 22, 2016 · Aptamer as therapeutic 1. WELCOME 2. Aptamers as TherapeuticsAptamers as Therapeutics Surender Kumar P1688 3. (apto: “to fit”& mer: “smallest unit of repeating structure”) single stranded folded oligonucleotides and peptide that bind to molecular (protein) targets with high affinity and specificity Provide opportunities for structure-based drug design strategies relevant to therapeutic ...
https://pubs.acs.org/doi/pdf/10.1021/mp500047b
Aptamer-Targeted DNA Nanostructures for Therapeutic Delivery Phapanin Charoenphol and Harry Bermudez* Department of Polymer Science and Engineering, University of Massachusetts, Amherst, Massachusetts 01003, United States ... aptamers to be attached per DNA pyramid via overhangs,
https://www.researchgate.net/publication/24442707_Aptamers_and_aptamer_targeted_delivery
The applications of aptamers range from diagnostics and biosensing, target validation, targeted drug delivery, therapeutics, templates for rational drug design to biochemical screening of small...
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