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https://onlinelibrary.wiley.com/doi/full/10.1002/cmdc.201402163
Aptamers as Drug Delivery Vehicles Sven Kruspe Institut für Biochemie und Molekularbiologie, Universität Hamburg, Martin‐Luther‐King Platz 6, 20146 Hamburg (Germany)Author: Sven Kruspe, Florian Mittelberger, Kristina Szameit, Ulrich Hahn
https://www.researchgate.net/publication/264625763_Aptamers_as_Drug_Delivery_Vehicles
Aptamers as Drug Delivery Vehicles. The benefits of directed and selective therapy for systemic treatment are reasons for increased interest in exploiting aptamers for cell-specific drug delivery. Nucleic acid based pharmaceuticals represent an interesting and novel tool to counter human diseases.
https://www.intechopen.com/books/role-of-novel-drug-delivery-vehicles-in-nanobiomedicine/aptamers-for-targeted-delivery-current-challenges-and-future-opportunities
Aptamers are synthetic ssDNA/RNA molecules that are emerging as novel tools for the development of therapeutics, especially for targeted delivery. Aptamers are comparable to monoclonal antibodies, which are well-established therapeutic molecules, in terms of specificity and affinity to their target.Author: Chetan Chandola, Muniasamy Neerathilingam
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107293/
Another derivation from nanoscaled drug delivery system, termed as “aptamer-drug conjugate,” has been generated to overcome the complicated assembly techniques and low controllability of site-specific drug conjugation 23.Author: Jie Zhu, He Huang, Shiwu Dong, Liang Ge, Yuan Zhang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
In the study conducted by Tong et al. , the sgc8c aptamer was conjugated to the surface of a viral capsid protein (MS2) by using chemoselective oxidative coupling reaction to construct a biodegradable drug-delivery vehicle. The interior of the viral capsid was modified and linked to the AlexaFluor 488 maleimide in order to detect it in cell-binding assays.Author: Partha Ray, Rebekah R. White
https://www.thno.org/v04p0931.pdf
nanotechnologies, current chemotherapy and drug delivery systems face great challenges. These challenges are due to the limitations of aptamers and vehicles and because of complicated tumor mechanisms, including heterogeneity, anti-cancer drug resistance, and hypoxia-induced aber-rances.
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