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https://www.i-sis.org.uk/Aptamers_for_Biosensing.php
Aptamers for therapy and new drugs Macugen, developed by Pfizer and Eyetech, is already commercially available for treating age-related macula degeneration, an eye disease that can lead to blindness. The drug is a polyethylene glycol-aptamer with specificity for VEGF165, which plays a critical role in angiogenesis (development of blood vessels) and permeability [17].
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329498/
Therefore, drug delivery to target cancer cells and tissues becomes one of the most important areas for cancer treatment. Aptamers, not only can be used for the diagnosis of different diseases as targeting ligands, but also can be used for the therapy of different diseases with enhanced therapeutic efficiency.Author: Xu Wu, Jiao Chen, Min Wu, Julia Xiaojun Zhao
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
Second, aptamers are structurally stable across a wide range of temperature and storage conditions, maintaining the ability to form their unique tertiary structures. Third, aptamers can be chemically synthesized, in contrast to the expensive and work-intensive biological systems needed to produce monoclonal antibodies.Author: Partha Ray, Rebekah R. White
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332121/
Nov 25, 2015 · DNA aptamers are used in two ways for targeted delivery of drugs: (1) directly linked to the drug molecules; (2) in combination with nanoparticles to form the delivery platform. Conjugating drug molecules directly to specific DNA aptamers is a potential way to deliver the drugs specifically, and thus reduce the risk of off-target drugs.Author: Qinchang Zhu, Ge Liu, Masaaki Kai
https://www.thno.org/v05p0322.pdf
affinity to targets, aptamers have attracted great attention in various fields in which selective recognition units are required. They have been used in biosensing, drug delivery, disease diagnosis and therapy (especially for cancer treatment). In this review, we summarized recent applications of DNA and RNA aptamers in cancer theranostics.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279232/
Jan 09, 2012 · Aptamers have been studied as a bio-material in numerous investigations concerning their use as a diagnostic and therapeutic tool and biosensing probe, and in the development of new drugs, drug delivery systems, etc. (Figure 1). There have been attempts to search for aptamers that are specific to targets involved in various diseases, such as cancer and viral infection.Author: Kyung-Mi Song, Seonghwan Lee, Changill Ban
https://www.nature.com/articles/s41698-017-0041-y
Nov 14, 2017 · Aptamers as a specific targeting molecule are used to discriminate various receptors and biomarkers on CRC cell surface, and it may be used in CRC early diagnosis. In CRC therapy, targeted-drug delivery systems could help clinicians to reduce effects of chemotherapeutic drugs. Aptamer has affinity and selectivity,...Author: Chan Chen, Shan Zhou, Yongqiang Cai, Faqing Tang, Faqing Tang
https://www.researchgate.net/publication/297678149_Aptamer-integrated_DNA_nanostructures_for_biosensing_bioimaging_and_cancer_therapy
Therefore, integrating aptamers into DNA nanostructures results in powerful tools for biosensing and bioimaging applications. Furthermore, owing to their high loading capability, aptamer-modified...
https://www.sciencedirect.com/science/article/pii/S0169409X10000724
Although aptamers are excellent candidates as diagnostic and drug delivery agents, there are still a few issues that have yet to be addressed for their practical applications. One issue is that nucleic acid aptamers could be vulnerable to nuclease degradation in cells or in blood [56].Author: Jung Heon Lee, Mehmet V. Yigit, Debapriya Mazumdar, Yi Lu
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