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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218254/
Aptamers for drug delivery The emerging integration of aptamers with nanotechnology and chemical biology is envisioned to produce more versatile target-specific molecules, stimulate further new diagnostic and therapeutic nanotechnologies, and provide significant potential for many research and clinical applications in the near future.Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
Aptamers therefore may be used to deliver molecules that are not otherwise taken up efficiently by cells (e.g., siRNAs) or to limit delivery of molecules that are efficiently taken up by cells (e.g., most chemotherapeutic agents) to cells that express aptamer targets.Author: Partha Ray, Rebekah R. White
https://www.sciencedirect.com/science/article/pii/S0167779911001132
The cell membrane is basically a dynamic lipid bilayer; therefore, this liposome nanostructure can efficiently increase cell permeability and enhance drug delivery. A cell-permeable sgc8–PEG–liposome nanostructure has also been reported for drug delivery . With approximately 250 aptamers on each liposome, this design leads to multiple aptamer–receptor interactions, provides better binding to the …Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://tan.chem.ufl.edu/wp-content/uploads/sites/39/pubs/important-articles/Molecular%20aptamers%20for%20drug%20delivery.pdf
Aptamers as delivery agents Aptamers can be designed as targeting ligands, particu- larly when generated by cell-based SELEX, and can dif- ferentiate diseased cells from healthy cells, thus enabling the selective delivery of therapeutic compounds to target cells (Table 1).
http://www.eurekaselect.com/111247/article?tracking-code=4
Aptamer researches applied to the treatment of human cancers have increased since their discovery in 1990. This is due to different factors including: 1) t...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205327/
Sep 01, 2011 · Aptamers exhibit many desirable properties for tumor-targeted drug delivery, such as ease of selection and synthesis, high binding affinity and specificity, low immunogenicity, and versatile synthetic accessibility. Over the last several years, aptamers have quickly become a new class of targeting ligands for drug delivery applications.Author: Yin Zhang, Hao Hong, Weibo Cai
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