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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
The sgc8c aptamer is therefore a promising candidate for targeted drug delivery. Huang et al. [ 38 ] covalently conjugated the anthracycline chemotherapeutic agent doxorubicin (Dox) to the sgc8c aptamer using an acid-labile hydrazone linkage.Author: Partha Ray, Rebekah R. White
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205327/
Sep 01, 2011 · Tumor-targeted drug delivery is one of the major areas in cancer research. Aptamers exhibit many desirable properties for tumor-targeted drug delivery, such as ease of selection and synthesis, high binding affinity and specificity, low immunogenicity, and versatile synthetic accessibility.Author: Yin Zhang, Hao Hong, Weibo Cai
https://www.researchgate.net/publication/45267619_Aptamers_for_Targeted_Drug_Delivery
Aptamers for Targeted Drug Delivery. Aptamers are a class of therapeutic oligonucleotides that form specific three-dimensional structures that are dictated by their sequences.
https://www.intechopen.com/online-first/aptamers-for-targeted-delivery-current-challenges-and-future-opportunities
Aptamers are synthetic ssDNA/RNA molecules that are emerging as novel tools for the development of therapeutics, especially for targeted delivery. Aptamers are comparable to monoclonal antibodies, which are well-established therapeutic molecules, in terms of specificity and affinity to their target.Author: Chetan Chandola, Muniasamy Neerathilingam
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043981/
Oct 30, 2010 · Decoration of DNA or RNA aptamers on delivery vehicles confers selectivity in cell type interactions and can result in cellular internalization in the target cells, thereby increasing the therapeutic efficacy and reducing potential toxicities of the payloads. These aptamers constitute a mechanism for targeted delivery of various drugs or therapeutic oligonucleotides as discussed below.Author: Jiehua Zhou, John J. Rossi
http://www.eurekaselect.com/111247/article?tracking-code=4
Aptamer researches applied to the treatment of human cancers have increased since their discovery in 1990. This is due to different factors including: 1) t...
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