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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033951/
This proof-of-principle study demonstrated that an anti-TN-C aptamer could be used to target tumors (glioma, breast, and colon) that express high level of TN-C and that aptamers, in general, may have pharmacologic properties that make them excellent agents for tumor-specific drug delivery.Author: Partha Ray, Rebekah R. White
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218254/
Aptamers for drug delivery. The emerging integration of aptamers with nanotechnology and chemical biology is envisioned to produce more versatile target-specific molecules, stimulate further new diagnostic and therapeutic nanotechnologies, and provide significant potential for many research and clinical applications in the near future. ...Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.nature.com/articles/nrd.2016.199
Nov 03, 2016 · There are three aptamers designated for use in ophthalmology, including one drug approved by the US Food and Drug Administration (FDA) (pegaptanib (Macugen)), and two in …Author: Jiehua Zhou, John Rossi
https://tan.chem.ufl.edu/wp-content/uploads/sites/39/pubs/important-articles/Molecular%20aptamers%20for%20drug%20delivery.pdf
Molecular aptamers for drug delivery Weihong 3 Tan1,2, Hui Wang2, Yan Chen1,2,3, Xiaobing Zhang1, Haizhen Zhu1, Chaoyong Yang , Ronghua Yang1 and Chen Liu2 1State Key Laboratory ofChemo/Biosensing andChemometrics, CollegeBiology, Chemistry Chemical
https://www.sciencedirect.com/science/article/pii/S0167779911001132
The cell membrane is basically a dynamic lipid bilayer; therefore, this liposome nanostructure can efficiently increase cell permeability and enhance drug delivery. A cell-permeable sgc8–PEG–liposome nanostructure has also been reported for drug delivery . With approximately 250 aptamers on each liposome, this design leads to multiple ...Author: Weihong Tan, Weihong Tan, Hui Wang, Yan Chen, Yan Chen, Yan Chen, Xiaobing Zhang, Haizhen Zhu, Chaoy...
https://www.aptagen.com/what-are-aptamers/drug-discovery-delivery/
The unique chemistry of aptamers, unlike other forms of drugs currently used, permits the natural selection of drug candidates in whole animal models, bypassing the test tube entirely, saving several years and approximately 35% of the R&D cost. By using an animal model with the disease state of interest, Aptagen need not possess specific knowledge of the pathology or disease condition in ...
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