We have collected information about Aptamer-Mediated Delivery Of Chemotherapy To Pancreatic Cancer Cells for you. Follow the links to find out details on Aptamer-Mediated Delivery Of Chemotherapy To Pancreatic Cancer Cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464421/
Gemcitabine is a nucleoside analog that is currently the best available single-agent chemotherapeutic drug for pancreatic cancer. However, efficacy is limited by our inability to deliver sufficient active metabolite into cancer cells without toxic effects on normal tissues.Author: Partha Ray, Marcus A. Cheek, Mariam L. Sharaf, Na Li, Andrew D. Ellington, Bruce A. Sullenger, Barba...
https://www.liebertpub.com/doi/full/10.1089/nat.2012.0353
Targeted delivery of gemcitabine into cancer cells could maximize effectiveness and concurrently minimize toxic side effects by reducing uptake into normal cells. Most pancreatic cancers overexpress epidermal growth factor receptor (EGFR), a trans-membrane receptor tyrosine kinase. We utilized a nuclease resistant RNA aptamer that binds and is internalized by EGFR on pancreatic cancer cells to deliver gemcitabine-containing polymers into EGFR-expressing cells and inhibit cell …Author: Partha Ray, Marcus A. Cheek, Mariam L. Sharaf, Na Li, Andrew D. Ellington, Bruce A. Sullenger, Barba...
https://www.researchgate.net/publication/231582001_Aptamer-Mediated_Delivery_of_Chemotherapy_to_Pancreatic_Cancer_Cells
Targeted delivery of gemcitabine into cancer cells could maximize effectiveness and concurrently minimize toxic side effects by reducing uptake into normal cells.
http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.1030.9441&rep=rep1&type=pdf
Aptamer-Mediated Delivery of Chemotherapy to Pancreatic Cancer Cells Partha Ray,1 Marcus A. Cheek,2 Mariam L. Sharaf,2 Na Li,3,* Andrew D. Ellington,3 Bruce A. Sullenger,1 Barbara Ramsay Shaw,2 and Rebekah R. White1 Gemcitabine is a nucleoside analog that is currently the best available single-agent chemotherapeutic drug for pancreatic cancer.
https://scholars.duke.edu/individual/pub800967
Aptamer-mediated delivery of chemotherapy to pancreatic cancer cells. Gemcitabine is a nucleoside analog that is currently the best available single-agent chemotherapeutic drug for pancreatic cancer. However, efficacy is limited by our inability to deliver sufficient active metabolite into cancer cells without toxic effects on normal tissues.
https://www.academia.edu/19940917/Aptamer-mediated_delivery_of_chemotherapy_to_pancreatic_cancer_cells
Gemcitabine is a nucleoside analog that is currently the best available single-agent chemotherapeutic drug for pancreatic cancer. However, efficacy is limited by our inability to deliver sufficient active metabolite into cancer cells without toxic
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3423875/
Because the nucleolin aptamer selectively localizes to the nuclei of cancer cells and efficiently internalizes into PC3 cells, we investigated whether the nucleolin aptamer could be utilized to deliver SSOs to the nucleus of PC3 cells containing a splice-switching luciferase report construct (PC3/Luc 705 cells).Author: Jonathan W. Kotula, Elizabeth D. Pratico, Xin Ming, Osamu Nakagawa, Rudolph L. Juliano, Bruce A. Sul...
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(18)30130-6
Sep 07, 2018 · Gemcitabine-Incorporated G-Quadruplex Aptamer for Targeted Drug Delivery into Pancreas Cancer Gemcitabine has been considered a first-line chemotherapy agent for the treatment of pancreatic cancer. However, the initial response rate of gemcitabine is low and chemoresistance occurs frequently.Author: Jun Young Park, Ye Lim Cho, Ju Ri Chae, Sung Hwan Moon, Won Gil Cho, Yun Jung Choi, Soo Jin Lee, Won...
https://www.sciencedirect.com/science/article/pii/S2162253117302974
Targeted Delivery of Auristatin-Modified Toxins to Pancreatic Cancer Using Aptamers ... Our results show that the best aptamer for targeted delivery of a toxin to a cell line cannot be chosen based on binding alone. ... A.D. Ellington, B.A. Sullenger, B.R. Shaw, R.R. WhiteAptamer-mediated delivery of chemotherapy to pancreatic cancer cells ...Author: Christina Kratschmer, Matthew Levy
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