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https://www.ncbi.nlm.nih.gov/pubmed/19062774
In addition, various drug delivery systems (e.g. liposomes, microspheres, nanoparticles, nanogels and bionanocapsules) have been used to enhance drug delivery to the brain.Author: Mayur M. Patel, Bhoomika R. Goyal, Shraddha V. Bhadada, Jay S. Bhatt, Avani F. Amin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4026551/
May 10, 2014 · Current approaches to enhance CNS delivery of drugs across the brain barriers Cui-Tao Lu , 1 Ying-Zheng Zhao , 2, 3 Ho Lun Wong , 4 Jun Cai , 5 Lei Peng , 2 and Xin-Qiao Tian 1 1 The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang Province, People’s Republic of ChinaAuthor: Cui-Tao Lu, Ying-Zheng Zhao, Ho Lun Wong, Jun Cai, Lei Peng, Xin-Qiao Tian
https://www.researchgate.net/publication/23638200_Getting_into_the_Brain_Approaches_to_Enhance_Brain_Drug_Delivery
In addition, various drug delivery systems (e.g. liposomes, microspheres, nanoparticles, nanogels and bionanocapsules) have been used to enhance drug delivery to the brain.
https://www.academia.edu/8463421/Getting_into_the_Brain_Approaches_to_Enhance_Brain_Drug_Delivery
Getting into the Brain: Approaches to Enhance Brain Drug Delivery
https://www.academia.edu/1946398/Getting_into_the_brain_approaches_to_enhance_brain_drug_delivery
Getting into the brain: approaches to enhance brain drug delivery
http://www.thno.org/v08p1481.pdf
a major barrier for brain tumor drug delivery. Strategies that are applied to overcome the BBB, including opening TJs by a hyperosmotic solution of mannitol or a compound (e.g., bradykinin), inhibiting efflux drug transporters, and receptormediated drug - delivery systems, may also be exploited to selectively enhance drug delivery to brain tumors.
https://www.ncbi.nlm.nih.gov/pubmed/24872687
May 10, 2014 · This article reviews the current approaches to open or facilitate penetration across these barriers for enhanced drug delivery to the CNS. These approaches are summarized into three broad categories: noninvasive, invasive, and miscellaneous techniques.Author: Cui-Tao Lu, Ying-Zheng Zhao, Ho Lun Wong, Jun Cai, Lei Peng, Xin-Qiao Tian
https://www.researchgate.net/profile/Shraddha_Bhadada2/publication/23638200_Getting_into_the_Brain_Approaches_to_Enhance_Brain_Drug_Delivery/links/0fcfd5110b0604ad2a000000/Getting-into-the-Brain-Approaches-to-Enhance-Brain-Drug-Delivery.pdf
1. Approaches to Enhance Brain Drug Delivery 38 1.1 Chemical Delivery Systems 38 1.1.1 Upid-iviediated Transport (Upidization of Smaii Moiecules) 38 1.1.2 Prodrug Approach 39 …
https://www.researchgate.net/publication/262693056_Current_approaches_to_enhance_CNS_delivery_of_drugs_across_the_brain_barriers
Different strategies for efficient CNS delivery have been studied. This article reviews the current approaches to open or facilitate penetration across these barriers for enhanced drug delivery to the CNS. These approaches are summarized into three broad categories:...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751454/
Feb 05, 2008 · Prodrug approaches are used to improve drug delivery and targeting in the CNS, and utilize passive drug uptake processes into CNS by chemically modifying a drug to become more lipophilic. Such chemical derivatives include, for example, “traditional” lipophilic esters and other lipophilic compounds that release brain-trapped intermediates, which are also referred to as chemical delivery …Author: Jarkko Rautio, Krista Laine, Mikko Gynther, Jouko Savolainen
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