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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507026/
Jul 06, 2012 · There are different viral and nonviral vectors for gene delivery, but all gene therapy applications depend on the fact that the genetic material needs to be delivered across the cell membrane and ultimately to the cell nucleus.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293995/
The potential of viruses as vectors for gene delivery was recognized even then. Viruses are among the simplest biological agents capable of delivering genetic information to a cell and have evolved properties that make them useful as vectors for gene delivery (Shen and Post, 2007). Structural virions carry and protect viral genetic information ...Author: Thomas B. Lentz, Steven James Gray, R. Jude Samulski
https://seekingalpha.com/article/4305556-gene-therapy-series-2-delivery-systems-in-gene-therapy-including-viral-vectors
Nov 11, 2019 · Non-viral methods of transgene delivery. Although viral vectors are being used in two-third of gene therapy programs, there are some non-viral methods of …
https://www.sciencedirect.com/science/article/pii/S0378595519305672
Gene therapy using virus vectors to treat hereditary diseases has made remarkable progress in the past decade. There are FDA-approved products for ex-vivo gene therapy for diseases such as immunodeficiencies (e.g., SCID), and in vivo gene therapy for a rare blindness and neuro-muscular disease. Gene therapy for hereditary hearing loss has picked up pace in the past five years due to …Author: Casey A. Maguire, David P. Corey
https://www.nature.com/articles/nrn1104
May 01, 2003 · The use of viral vectors to deliver genes to the nervous system shows great promise for both basic research and therapeutic applications. However, the brain presents a …Author: Beverly L. Davidson, Xandra O. Breakefield
https://www.thermofisher.com/us/en/home/references/gibco-cell-culture-basics/transfection-basics/gene-delivery-technologies/viral-delivery/viral-vectors.html
For cell types not amenable to lipid-mediated transfection, viral vectors are often employed. Virus-mediated transfection, also known as transduction, offers a means to reach hard-to-transfect cell types for protein overexpression or knockdown, and it is the most commonly used method in clinical research (Glover et al., 2005; Pfeifer and Verma, 2001).
https://www.addgene.org/viral-vectors/
Then, those viruses can be used to deliver the "memory" gene (and thus, that protein) to the brain in mice and see if they are better able to remember how to solve a maze. These engineered viral genomes are also modified (relative to natural viruses) for safety through the removal of certain genes that are required for viral replication.
https://www.sciencedirect.com/science/article/pii/S0024320520302988
In this regard, biological and non-biological gene delivery vectors are used to protect the naked foreign DNA to mediate effective tissue entry of the desired gene of interest. In this review, the use of bacterial and viral vectors for breast cancer gene therapy was summarized.Author: Balamurugan Shanmugaraj, Lohanathan Bharathi Priya, B. Mahalakshmi, Shanmugam Subbiah, Rouh-Mei Hu, ...
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