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https://www.sciencedirect.com/science/article/pii/S0024320520302988
4. Vaccine delivery methods. Non-viral vectors such as cationic lipids and polycationic polymers are used as DNA delivery agents in gene therapy [8,34]. These molecules form electrostatic interactions with DNA, thereby protects DNA from nucleases and cellular defense mechanism.Author: Balamurugan Shanmugaraj, Lohanathan Bharathi Priya, B. Mahalakshmi, Shanmugam Subbiah, Rouh-Mei Hu, ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710930/
Jul 03, 2013 · Adenovirus. Adenoviruses (Ads) have been extensively studied for their potential usage in gene therapy applications. Owing to years of research, which has established a foundation for the use of this linear double-stranded DNA virus as a vector for vaccine delivery, Ads have become one of the most exploited vectors for vaccine development.Author: Youngjoo Choi, Jun Chang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040527/
Summary. A variety of DNA and RNA viruses are being used to develop RC viral vectors for HIV vaccine delivery. Multiple viral vector platforms have proven to be safe and immunogenic with evidence of efficacy in macaques.Author: Christopher L. Parks, Louis J. Picker, C. Richter King
https://ktn-uk.co.uk/news/viral-vectors-for-vaccines-and-gene-delivery
Viral vectors for vaccine, and cell and gene therapy products have shown unprecedented clinical promise; however the manufacturing platforms for their commercial production are in their infancy when compared to therapeutic proteins. When analysing current process performance, major challenges emerge in both upstream and downstream operations: in USP the low titre and presence of large ...
https://www.sciencedirect.com/science/article/pii/B9780128023020000017
Introduction. The development of a safe and effective vaccine is a long and challenging process, irrespective of the target pathogen. This is particularly true for human immunodeficiency virus (HIV), where there have been both unique and prototypical obstacles to creating vaccine delivery technologies that elicit sufficient acquired immunity to prevent or abort HIV infection, or control viral ...Author: C.L. Parks
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