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https://www.nature.com/articles/nrg3763
Jul 15, 2014 · Figure 1: Barriers to successful in vivo delivery of nucleic acids using non-viral vectors. Figure 2: Chemical structures of non-viral DNA vectors. Figure 3: Structure of non-viral siRNA vectors.Author: Hao Yin, Rosemary L. Kanasty, Ahmed A. Eltoukhy, Arturo J. Vegas, Arturo J. Vegas, J. Robert Dorkin,...
https://www.intechopen.com/books/gene-therapy-tools-and-potential-applications/non-viral-delivery-systems-in-gene-therapy
Gene delivery systems include viral vectors and non-viral vectors. Viral vectors are the most effective, but their application is limited by their immunogenicity, oncogenicity and the small size of the DNA they can transport. Non-viral vectors are safer, of …
https://www.nature.com/articles/nrn1104
The use of viral vectors to deliver genes to the nervous system shows great promise for both basic research and therapeutic applications. However, the brain presents a challenging target for gene ...
https://www.researchgate.net/publication/255755059_Dendrimers_as_Non-Viral_Vectors_for_siRNA_Delivery
The present review offers a brief overview of the current status of dendrimers as siRNA delivery vectors, focusing on the different dendrimers investigated for their siRNA delivery ability and the ...
https://www.intechopen.com/books/rna-interference/non-viral-sirna-and-shrna-delivery-systems-in-cancer-therapy
Development of appropriate delivery systems is an important issue in the use of siRNA-based therapeutics. Non-viral delivery systems have great potential for safe and effective delivery of siRNA therapeutics to tumor cells. Nanocarriers such as nanoplexes, lipoplexes, nanoparticles, and liposomes have been commonly used for siRNA delivery.
https://insights.bio/cell-and-gene-therapy-insights/journal/articles/non-viral-vector-mediated-gene-delivery-the-outsider-to-watch-out-for-in-gene-therapy/
Taking into account the substantial technical progress in safety for viral delivery and efficiency for non-viral delivery, as well as methods used in ongoing gene therapy pre-clinical and clinical trials, there is an emerging tendency for a dedicated scope of use for each method.
https://www.thermofisher.com/us/en/home/references/ambion-tech-support/rnai-sirna/tech-notes/enhanced-sirna-delivery-and-long-term-gene-silencing.html
Figure 1. Gene Silencing After Retroviral Delivery of siRNA. Retroviral vectors expressing the indicated siRNA inserts from either the H1 or U6 promoter were transfected into a retrovirus packaging cell line in 6 well plates. Three days following infection, virus was collected and used to infect HeLa cells in triplicate.
https://febs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1742-4658.2010.07904.x
ing efficient siRNA delivery in vivo and discusses recent advances in over-coming them using chemically modified siRNA, viral siRNA vectors and nonviral siRNA carriers. Enhanced specificity and efficiency of RNAi in vivo via selective accumulations in desired tissues, specific binding to
https://www.researchgate.net/publication/263935637_Non-viral_vectors_for_gene-based_therapy
Non-viral vectors for gene-based therapy. ... nanotechnology and nucleic acid chemistry that have yielded promising non-viral delivery systems, some of which are currently undergoing testing in ...
https://pubs.acs.org/doi/10.1021/mp070048k
Both viral and nonviral vectors are being assessed for siRNA delivery to lung cells. Viral vectors have been developed for efficient delivery of siRNA into a range of mammalian cells. Genetic material inserted into the vector can encode for shRNA which efficiently blocks production of a specific protein.
https://en.wikipedia.org/wiki/Small_interfering_RNA
Viral-mediated delivery. The gene silencing effects of transfected designed siRNA are generally transient, but this difficulty can be overcome through an RNAi approach. Delivering this siRNA from DNA templates can be done through several recombinant viral vectors based on retrovirus, adeno-associated virus, adenovirus, and lentivirus.
https://www.hindawi.com/journals/jnm/2011/742895/
Small interfering RNAs (siRNAs) technology has emerged as a promising potential treatment for viral, genetic diseases and cancers. Despite the powerful therapeutic potential of siRNA, there are challenges for developing efficient and specific delivery systems for systemic administration. There are extracellular and intracellular barriers for nanoparticle-mediated delivery. First, nanoparticles ...
http://www.genetherapynet.com/viral-vectors.html
Viral vectors have natural host cell populations that they infect most efficiently. Retroviruses have limited natural host cell ranges, and although adenovirus and adeno-associated virus are able to infect a relatively broader range of cells efficiently, some cell types are refractory to infection by these viruses as well. Attachment to and entry into a susceptible cell is mediated by the ...
http://www.genetherapynet.com/non-viral-vectors.html
Non-viral methods present certain advantages over viral methods, with simple large scale production and low host immunogenicity being just two. Previously, low levels of transfection and expression of the gene held non-viral methods at a disadvantage; however, recent advances in vector technolog...
https://jbioleng.biomedcentral.com/articles/10.1186/1754-1611-6-7
Numerous non-viral carriers including natural and synthetic polymers, polyplexes, liposomes, lipoplexes, peptides, dendrimers and free nucleic acid pressurized hydrodynamic injections, as well as virus-based vectors and plasmids encoding for siRNA, have been proposed for siRNA delivery.
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