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https://www.nature.com/articles/nature05901
Jun 17, 2007 · Attachment of a piece of viral protein to a small RNA achieves transfer of the RNA into neuronal cells in cell culture. This was also able to deliver an antiviral siRNA specifically into the ...Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
RNA interference (RNAi) is caused by small (21 − 23 bases long) single-stranded RNA molecules (small-interfering RNA; siRNA), which trigger silencing of target genes in a sequence-specific manner [1,2]. The siRNA's sequence is ‘anti-sense’ (or complementary) to a specific stretch of the messenger RNA (mRNA) transcribed by the target gene.Author: Saroj P Mathupala
https://www.researchgate.net/publication/6263796_Transvascular_delivery_of_small_interfering_RNA_to_the_central_nervous_system
Transvascular delivery of small interfering RNA to the central nervous system Article (PDF Available) in Nature 448(7149):39-43 · August 2007 with 460 Reads How we measure 'reads'
http://adsabs.harvard.edu/abs/2007Natur.448...39K
A major impediment in the treatment of neurological diseases is the presence of the blood-brain barrier, which precludes the entry of therapeutic molecules from blood to brain. Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA) to the brain.
https://ohsu.pure.elsevier.com/en/publications/transvascular-delivery-of-small-interfering-rna-to-the-central-ne-2
Jul 07, 2007 · A major impediment in the treatment of neurological diseases is the presence of the blood-brain barrier, which precludes the entry of therapeutic molecules from blood to brain. Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA) to the brain.Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...
https://www.ncbi.nlm.nih.gov/pubmed/30143435
Nov 07, 2018 · Here we show that transient osmotic disruption of the BBB enables transvascular delivery of hydrophobically modified small interfering RNA (hsiRNA) to the rat brain. Intracarotid administration of 25% mannitol and hsiRNA conjugated to phosphocholine-docosahexanoic acid (PC-DHA) resulted in broad ipsilateral distribution of PC-DHA-hsiRNAs in the ...Author: Bruno M.D.C. Godinho, Nils Henninger, James Bouley, Julia F. Alterman, Reka A. Haraszti, James W. Gi...
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