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https://www.nature.com/articles/nature05901
Jun 17, 2007 · Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA…Author: Priti Kumar, Haoquan Wu, Jodi L. McBride, Kyeong-Eun Jung, Moon Hee Kim, Beverly L. Davidson, Sang K...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
RNA interference (RNAi) is caused by small (21 − 23 bases long) single-stranded RNA molecules (small-interfering RNA; siRNA), which trigger silencing of target genes in a sequence-specific manner [1,2]. The siRNA's sequence is ‘anti-sense’ (or complementary) to a specific stretch of the messenger RNA (mRNA) transcribed by the target gene.Author: Saroj P Mathupala
http://adsabs.harvard.edu/abs/2007Natur.448...39K
Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA) to the brain. This 29-amino-acid peptide specifically binds to the acetylcholine receptor expressed by neuronal cells.
https://www.the-scientist.com/papers-to-watch/transvascular-sirna-delivery-46181
Transvascular siRNA Delivery The tight network of endothelial cells of brain capillaries have, until now, kept therapeutic molecules, such as small interfering RNAs (siRNAs), from crossing from the blood into the brain. Such molecules could potentially silence targeted genes expressed in neurologic disorders. N.
https://www.academia.edu/18044726/Transvascular_delivery_of_small_interfering_RNA_to_the_central_nervous_system
Transvascular delivery of small interfering RNA to the central nervous system
https://www.researchgate.net/publication/6263796_Transvascular_delivery_of_small_interfering_RNA_to_the_central_nervous_system
Here we show that a short peptide derived from rabies virus glycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA) to the brain. This 29-amino-acid peptide...
https://www.nature.com/articles/ncpneuro0596
Transvascular delivery of siRNA to the CNS mediated by RVG–9R results in a gene-silencing effect comparable to that of direct injection, with the effect declining at a similar rate.
https://www.researchgate.net/profile/Jodi_Mcbride2/publication/6263796_Transvascular_delivery_of_small_interfering_RNA_to_the_central_nervous_system/links/553d86600cf2c415bb0f72d4/Transvascular-delivery-of-small-interfering-RNA-to-the-central-nervous-system.pdf
entryoftherapeuticmoleculesfrombloodtobrain.Hereweshowthatashortpeptidederivedfromrabiesvirusglycoprotein (RVG) enables the transvascular delivery of small interfering RNA (siRNA) to the brain....
https://dspace.mit.edu/handle/1721.1/72914
RNA interference (RNAi) provides a direct way to assess and act on putative cancer targets. However, the translation of RNAi into the clinic has been thwarted by the "delivery" challenge, as small interfering RNA (siRNA) therapeutics must overcome clearance mechanisms and penetrate into tumor tissues to access cancer cells.
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