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https://www.nature.com/articles/nm1200_1403
Dec 01, 2000 · Transcutaneous immunization, a topical vaccine application, combines the advantages of needle-free delivery while targeting the immunologically …Author: Gregory M. Glenn, David N. Taylor, Xiuru Li, Sarah Frankel, Andrew Montemarano, Carl R. Alving
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3252672/
Dec 08, 2011 · Transcutaneous immunization by topical drug-delivery systems incorporating antigens avoids direct contact between potent adjuvants (sometimes slightly toxic) and the general circulation, hence offering the advantages of rapid distribution, self-administration, and enhanced safety.5,6 Due to its easy-to-use, needle-free, and noninvasive features, transcutaneous immunization represents an attractive alternative to vaccine delivery …Author: Ni Li, Li-Hua Peng, Xi Chen, Shinsaku Nakagawa, Jian-Qing Gao
https://www.sciencedirect.com/science/article/pii/S0264410X00005065
Transcutaneous immunization (TCI) is a novel immunization strategy by which antigen and adjuvant are applied topically to intact, hydrated skin to induce potent antibody and cell-mediated immune responses specific for both the antigen and the adjuvant.Author: Scott A Hammond, Deborah Walwender, Carl R Alving, Gregory M Glenn
https://www.frontiersin.org/articles/10.3389/fimmu.2020.00266/full
Transcutaneous immunization (TCI) via needle-free and non-invasive drug delivery systems is a promising approach to overcome current limitations of conventional parenteral vaccination methods.
https://link.springer.com/protocol/10.1385%2F1-59259-083-7%3A315
Transcutaneous immunization (TCI), the introduction of antigens using a topical application to intact skin, is a new technology that has both practical and immunological merits. Practically speaking,...
https://www.sciencedirect.com/science/article/pii/S0264410X11015556
Transcutaneous immunization shown to induce humoral and cellular immunity. Optimal formulation developed for patch stability and delivery. High throughput process used to identify excipients to stabilize macromolecules. Disc matrix-supported drying process used to produce stable dry vaccine patch.Author: Robert C. Seid, Jee Loon Look, Christian Ruiz, Vladimir Frolov, David Flyer, Jason Schafer, Larry El...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC96435/
Transcutaneous immunization (TCI) is a new technique that uses the application of vaccine antigens in a solution on the skin to induce potent antibody responses without systemic or local toxicity. We have previously shown that cholera toxin (CT), a potent ...Author: Gregory M. Glenn, Tanya Scharton-Kersten, Russell Vassell, Gary R. Matyas, Carl R. Alving
https://www.sciencedirect.com/science/article/pii/S0264410X06005731
A promising vaccination approach is the transcutaneous delivery of antigen in the form of a patch, as the skin is a potent immunological site with abundant antigen presenting cells. Transcutaneous immunization (TCI) is also capable of inducing broader immune responses because it targets the Langerhans and dermal dendritic cells, which reside in the epidermis and dermis [1] , [2] .Author: Ioanna Skountzou, Fu-Shi Quan, Joshy Jacob, Richard W. Compans, Sang-Moo Kang
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