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https://www.sciencedirect.com/science/article/pii/S1053429698800428
Transvascular Drug Delivery in Solid Tumors f arz Yua12 The microvessel wall is a barrier for the delivery of various therapeutic agents to tumor cells. Tumor mi- crovessels are, in general, more permeable to macromol- ecules than normal vessels.Author: Fan Yuan
https://www.ncbi.nlm.nih.gov/pubmed/9634493
Transvascular drug delivery in solid tumors. Yuan F(1). Author information: (1)Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA. The microvessel wall is a barrier for the delivery of various therapeutic agents to tumor cells.Author: Fan Yuan
https://www.sciencedirect.com/science/article/abs/pii/S1053429698800428
The ultrastructure is dynamic and can be modulated by the tumor microenvironment. The microenvironment itself can be altered by the transvascular transport because the transport may facilitate angiogenesis, reduce blood flow, and induce interstitial hypertension in tumors.Author: Fan Yuan
https://scholars.duke.edu/display/pub807847
The ultrastructure is dynamic and can be modulated by the tumor microenvironment. The microenvironment itself can be altered by the transvascular transport because the transport may facilitate angiogenesis, reduce blood flow, and induce interstitial hypertension in tumors.
https://link.springer.com/article/10.1023%2FA%3A1025785505977
Sep 01, 2003 · Drug delivery to solid tumors consists of multiple processes, including transport via blood vessels, transvascular transport, and transport through interstitial spaces. These processes are dynamic and change with time and tumor properties and are affected by multiple physicochemical factors of a drug, multiple tumor biologic factors, and as a consequence of drug treatments.Author: Seong Hoon Jang, M. Guillaume Wientjes, Dan Lu, Jessie L.-S. Au
https://www.researchgate.net/publication/231583060_Drug_Delivery_and_Transport_to_Solid_Tumors
Drug delivery to solid tumors consists of multiple processes, including transport via blood vessels, transvascular transport, and transport through interstitial spaces.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106925/
Jul 22, 2014 · The complexity of the in vivo system thus inflicts multiple biological barriers which impedes NP drug delivery to solid tumors. 2 In current anti-cancer therapies, NPs are generally administered intravenously (IV). This route is fast, reliable and allows complete distribution via the systemic circulation.Author: Shravan Kumar Sriraman, Bhawani Aryasomayajula, Vladimir P Torchilin
https://www.sciencedirect.com/science/article/pii/S0168365917308490
The vessel normalization hypothesis defines a strategy to increase passive transvascular drug delivery into tumors through the use of anti-angiogenic therapies that target VEGF and its downstream signaling partners . VEGF was initially discovered as a vascular permeability factor by Harold Dvorak .Author: Susy M. Kim, Peggy H. Faix, Jan E. Schnitzer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065247/
Interstitial hypertension and impaired blood supply reduces the efficacy and delivery of therapeutic agents in solid tumors. 16 The subsequent hypoxia in tumor cells not only induces resistance to radiotherapy, but also causes resistance to several cytotoxic drugs. Independent of these effects, the genetic instability induced by hypoxia selects for cells with an increased potential for metastatasis.Author: Rakesh K. Jain, Triantafyllos Stylianopoulos
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832007/
Nov 12, 2013 · Perfused vessels are necessary for enabling adequate oxygenation and distribution of systemically administered drugs in solid tumors. However, perfusion rates in some regions of a tumor can be significantly lower than that in the peritumor normal tissue, leading to hypoxia, low pH, and inadequate drug delivery.Author: Triantafyllos Stylianopoulos, Rakesh K. Jain
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