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https://www.sciencedirect.com/science/article/pii/S0169409X12003201
The EPR effect for macromolecular drug delivery to solid tumors: ... Augmentation of the EPR effect and macromolecular drug delivery to tumors. As Table 1 shows, we and others have identified permeability factors, such as bradykinin, NO, and prostaglandins, that facilitate extravasation or the EPR effect in cancer tissues. Generation of these ...Author: Hiroshi Maeda, Hideaki Nakamura, Jun Fang
https://www.sciencedirect.com/science/article/abs/pii/S0169409X12003201
The EPR effect for macromolecular drug delivery to solid tumors: ... We also commented a key difference between passive tumor targeting and the EPR effect in tumors, particularly as related to drug retention in tumors: passive targeting of low-molecular-weight X-ray contrast agents involves a retention period of less than a few minutes, whereas ...Author: Hiroshi Maeda, Hideaki Nakamura, Jun Fang
https://www.researchgate.net/publication/232609469_The_EPR_effect_for_macromolecular_drug_delivery_to_solid_tumors_Improvement_of_tumor_uptake_lowering_of_systemic_toxicity_and_distinct_tumor_imaging_in_vivo
The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo
https://www.ncbi.nlm.nih.gov/pubmed/20441782
Mar 18, 2011 · For example, angiogenesis leads to high vascular density in solid tumors, large gaps exist between endothelial cells in tumor blood vessels, and tumor tissues show selective extravasation and retention of macromolecular drugs. This EPR effect served as a basis for development of macromolecular anticancer therapy.Author: Jun Fang, Hideaki Nakamura, Hiroshi Maeda
https://www.ncbi.nlm.nih.gov/pubmed/20217587/
Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targeting. Greish K(1). Author information: (1)Department of Pharmaceuticals and Pharmaceutical Chemistry, and Utah Center for Nanomedicine, University of Utah, Salt Lake City, UT, USA.Author: Khaled Greish
https://onlinelibrary.wiley.com/doi/full/10.1111/j.1349-7006.2009.01323.x
Nov 11, 2009 · NG‐enhanced macromolecular drug delivery (EPR effect) to S‐180 tumors. We investigated whether NG altered the EPR effect, that is, the delivery of macromolecular drugs (Evans blue/albumin complex) to tumors and inflammatory sites. ... Enhancement of delivery of radioactive polymeric macromolecular drug to solid tumors.Author: Takahiro Seki, Takahiro Seki, Jun Fang, Hiroshi Maeda, Hiroshi Maeda
https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.12152
growth factor. Although most solid tumors, including human tumors, show the EPR effect, heterogeneity of tumor tissue may impede drug delivery. This review describes the barriers and countermeasures for improved drug delivery to tumors by using nanomedicines. (Cancer Sci 2013; 104: 779–789) A s the recipient of the Tomizo Yoshida Award of theAuthor: Hiroshi Maeda
https://www.nature.com/articles/natrevmats201614
Apr 26, 2016 · Maeda, H., Nakamura, H. & Fang, J. The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of …Author: Stefan Wilhelm, Anthony J. Tavares, Qin Dai, Seiichi Ohta, Seiichi Ohta, Julie Audet, Harold F. Dvor...
https://link.springer.com/chapter/10.1007%2F978-1-4614-7876-8_23
Jul 10, 2013 · The EPR effect has been considered as an alternative method for delivery of conventional anticancer drugs, and favorable bio-distribution of cancer therapeutic nanoparticles in blood would be considered to achieve a high level of accumulation in solid tumors.Author: Ji Young Yhee, Sejin Son, Sohee Son, Min Kyung Joo, Ick Chan Kwon
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