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https://www.ncbi.nlm.nih.gov/pubmed/27020469
INTRODUCTION: There are 2 misconceptions about the cerebrospinal fluid (CSF), the blood-brain barrier (BBB), and brain drug delivery, which date back to the discovery of a barrier between blood and brain over 100 years ago. Misconception 1 is that drug distribution into CSF is a measure of BBB transport.Author: William M. Pardridge
https://www.sciencedirect.com/science/article/pii/S0169409X11002900
5.2. Transport system-mediated drug delivery across the blood–brain barrier. The combination of endogenous transport systems present in the BBB and macromolecular conjugates or surface enhanced nano-particulate delivery systems such as liposomes, nanoparticles and supermolecular complexes has been utilised to access the brain.Author: Yan Chen, Lihong Liu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388327/
The presence of the blood-brain barrier (BBB) is a significant impediment to the delivery of therapeutic agents to the brain for treatment of brain diseases. Focused ultrasound (FUS) has been developed as a non-invasive method for transiently increasing the permeability of the BBB to promote drug delivery to targeted regions of the brain.Author: Alison Burgess, Kullervo H. Hynynen
https://www.drugtargetreview.com/news/36234/deliver-blood-brain/
Oct 19, 2018 · Drug delivery through the blood-brain barrier has shown to be difficult to overcome, but researchers may have discovered a method to overcome this issue… Research on the delivery of therapeutics to the brain could have implications for the treatment of a wide range of diseases, such as Alzheimer’s, ALS, brain cancer and Parkinson’s.
https://www.sciencedirect.com/science/article/pii/S0168365916303236
The CNS has developed a series of barriers to protect itself from invading pathogens, neurotoxic molecules and circulating blood cells. These structures with diverse degrees of permeability include the blood–cerebrospinal fluid (CSF) barrier, the blood–brain barrier (BBB), the blood–retinal barrier and the blood–spinal cord barrier .Among these, the BBB is the most extensive and exclusive.Author: Cláudia Saraiva, Catarina Praça, Raquel Ferreira, Tiago Santos, Lino Ferreira, Liliana Bernardino
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