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https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201909345
The targeted delivery of chemotherapeutic drugs is a major challenge in the clinical treatment of cancer. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier of the highly potent platinum‐based DNA intercalator, 56MESS.Author: Tiantian Wu, Tiantian Wu, Jianbing Liu, Manman Liu, Shaoli Liu, Shaoli Liu, Shuai Zhao, Shuai Zhao, ...
https://www.researchgate.net/publication/335016103_A_Nanobody-Conjugated_DNA_Nanoplatform_for_Targeted_Platinum_Drug_Delivery
Targeted delivery and controlled release of inactive platinum (Pt) prodrugs may offer a new approach to improve the efficacy and tolerability of the Pt family of drugs, which are used to treat 50% ...
https://pubs.rsc.org/en/content/articlelanding/2019/cc/c9cc01391a#!
A multifunctional nanobody–drug conjugate (NDC) was constructed in this work for the targeted delivery of a platinum prodrug and an MRI contrast agent. The NDC can be specifically internalized into EGFR positive cancer cells, resulting in higher therapeutic effect and lower side-effects relative to cisplatin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4792284/
Mar 09, 2016 · The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs. ... Protection of the encapsulated siRNAs from degradation by nucleases was observed and the combined delivery of the platinum agent and the siRNAs provided a chemotherapeutic enhancement of over 10-fold in in vitro cytotoxicity assays. 8 ...Author: Timothy C. Johnstone, Kogularamanan Suntharalingam, Stephen J. Lippard
https://onlinelibrary.wiley.com/doi/abs/10.1002/ppsc.201900418
Dec 11, 2019 · Degradable Nanomotors Using Platinum Deposited Complex of Calcium Carbonate and Hyaluronate Nanogels for Targeted Drug Delivery. Hyunsik Choi. Department of Materials Science and Engineering, 77 Cheongam‐ro, Nam‐gu, Pohang, Gyeongbuk, 790‐784 Korea.Author: Hyunsik Choi, Byung Woo Hwang, Kyeng Min Park, Ki Su Kim, Sei Kwang Hahn
https://www.sciencedirect.com/science/article/pii/S0223523420301963
3. Drug targeting and delivery systems. Selective drug delivery is an important approach with great potential for overcoming problems associated with the systemic toxicity of chemotherapy, in particular, platinum-based chemotherapy [23,24].Targeted drug therapy has two advantages over conventional chemotherapy: preventing damage to normal tissues and reducing drug resistance [].
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582270/
Nov 11, 2008 · We therefore devised a strategy for cisplatin therapy in prostate cancer based on mechanisms that target critical molecular pathways of prostate tumors and that employ platinum chemistry and delivery vehicles for such targeting. Targeted controlled release drug delivery systems have the potential to induce dramatic and durable clinical responses.Author: Shanta Dhar, Frank X. Gu, Robert Langer, Omid C. Farokhzad, Omid C. Farokhzad, Stephen J. Lippard
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