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https://wyss.harvard.edu/media-post/dna-nanorobot-cell-targeted-payload-delivering/
DNA Nanorobot: Cell-Targeted, Payload-Delivering Previous Next. This video describes a cell-targeted, payload-delivering DNA nanorobot developed at the Wyss Institute that can trigger targeted therapeutic responses. This novel technology could potentially seek out …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100918/
May 17, 2011 · One option to achieve targeted delivery is conjugation of haptens to payload, and subsequent complexion with hapten-binding bispecific antibodies. Complexion via antibody-antigen interaction AVOIDS chemical modification of antibodies and thereby reduces risks of inactivating the targeting entity or generating immunogenic sites within the protein.Author: Silke Metz, Alexander K. Haas, Karin Daub, Rebecca Croasdale, Jan Stracke, Wilma Lau, Guy Georges, H...
http://www.freepatentsonline.com/y2020/0054676.html
Feb 20, 2020 · In some embodiment, the aforementioned payload of drug in the drug delivery platform is further internalized by the target cell when the small ligand binds to at least one component of the engineered protein. In some embodiment, the aforementioned drug delivery platform has a releasable linker to connect the small ligand and the payload drug.Author: Low Philip S, Srinivasarao Madduri, Zhang Boning
https://mct.aacrjournals.org/content/15/11/2688
Nov 01, 2016 · Efficient Payload Delivery by a Bispecific Antibody–Drug Conjugate Targeting HER2 and CD63 Bart E.C.G. de Goeij, Tom Vink, Hendrik ten Napel, Esther C.W. Breij, David Satijn, Richard Wubbolts, David Miao and Paul W.H.I. Parren Bart E.C.G. de Goeij Genmab, Utrecht, the Netherlands.Author: Bart E.C.G. de Goeij, Tom Vink, Hendrik ten Napel, Esther C.W. Breij, David Satijn, Richard Wubbolts...
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201902952
Securing the Payload, Finding the Cell, and Avoiding the Endosome: Peptide‐Targeted, Fusogenic Porous Silicon Nanoparticles for Delivery of siRNAAuthor: Byungji Kim, Si Sun, Judith A. Varner, Stephen B. Howell, Erkki Ruoslahti, Michael J. Sailor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4755198/
Feb 10, 2016 · Another principle for payload delivery via hapten‐binding bsAbs is ‘pretargeting’ 70, 71, 72, 73. In this concept, targeting vehicles and payloads are not combined prior to application. Instead, delivery (or capture) vehicles are applied without payload first to enable their distribution and binding to desired target sites.Author: Stefan Dengl, Claudio Sustmann, Ulrich Brinkmann
https://www.researchgate.net/publication/51092948_Bispecific_digoxigenin-binding_antibodies_for_targeted_payload_delivery
targeted delivery is conjugation of haptens to payload, and sub- sequent complexion with hapten-binding bispecific antibodies. Complexion via antibody-antigen interaction AVOIDS chemical
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