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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202607/
May 01, 2010 · RNA interference (RNAi) is a powerful approach for silencing genes associated with a variety of pathologic conditions; however, in vivo RNAi delivery has remained a major challenge due to lack of safe, efficient, and sustained systemic delivery. Here, we report on a novel approach to overcome these limitations using a multistage vector composed of mesoporous silicon particles (stage 1 ...Author: Takemi Tanaka, Takemi Tanaka, Lingegowda S. Mangala, Pablo E. Vivas-Mejia, René Nieves-Alicea, Aman ...
https://www.ncbi.nlm.nih.gov/pubmed/20430760
May 01, 2010 · Sustained small interfering RNA delivery by mesoporous silicon particles. Tanaka T(1), Mangala LS, Vivas-Mejia PE, Nieves-Alicea R, Mann AP, Mora E, Han HD, Shahzad MM, Liu X, Bhavane R, Gu J, Fakhoury JR, Chiappini C, Lu C, Matsuo K, Godin B, Stone RL, Nick AM, Lopez-Berestein G, Sood AK, Ferrari M.Author: Takemi Tanaka, Takemi Tanaka, Lingegowda S. Mangala, Pablo E. Vivas-Mejia, René Nieves-Alicea, Aman ...
https://www.researchgate.net/publication/43354714_Sustained_Small_Interfering_RNA_Delivery_by_Mesoporous_Silicon_Particles
A potential way of mitigating cancer is through RNA interference (RNAi) by the delivery of small interfering RNA (siRNA) to target select proteins or genes involved in cancer progression, known as ...
https://www.researchgate.net/profile/Ciro_Chiappini/publication/43354714_Sustained_Small_Interfering_RNA_Delivery_by_Mesoporous_Silicon_Particles/links/0912f50e42a98a8e6e000000/Sustained-Small-Interfering-RNA-Delivery-by-Mesoporous-Silicon-Particles.pdf
Therapeutics, Targets, and Chemical Biology Sustained Small Interfering RNA Delivery by Mesoporous Silicon Particles Takemi Tanaka1,9, Lingegowda S. Mangala2, Pablo E. Vivas-Mejia11, René Nieves ...
https://www.sciencedirect.com/science/article/pii/S1742706118303337
A low toxicity and efficient delivery system is needed to deliver small interfering RNAs (siRNA) in vitro and in vivo.The use of mesoporous silica nanoparticles (MSN) is becoming increasingly common due to its biocompatibility, tunable pore size and customizable properties.Author: Coline Pinese, Coline Pinese, Junquan Lin, Ulla Milbreta, Mingqiang Li, Yucai Wang, Kam W. Leong, Si...
https://scholars.houstonmethodist.org/en/publications/sustained-small-interfering-rna-delivery-by-mesoporous-silicon-particles(a2cd7cf8-b0c7-4871-a11b-1a27f5255a2b).html
Takemi Tanaka, Lingegowda S. Mangala, Pablo E. Vivas-Mejia, René Nieves-Alicea, Aman P. Mann, Edna Mora, Hee Dong Han, Mian M.K. Shahzad, Xuewu Liu, Rohan Bhavane ...Author: Takemi Tanaka, Takemi Tanaka, Lingegowda S. Mangala, Pablo E. Vivas-Mejia, René Nieves-Alicea, Aman ...
https://www.academia.edu/9535205/Sustained_Small_Interfering_RNA_Delivery_by_Mesoporous_Silicon_Particles
Sustained Small Interfering RNA Delivery by Mesoporous Silicon Particles
https://link.springer.com/protocol/10.1007/978-1-62703-547-7_36
Jun 24, 2013 · RNA interference Small interfering RNA Nanoparticle Liposome Multistage delivery Ovarian cancer Sustained gene silencing Mesoporous silicon particle This is a preview of subscription content, log in to check access.Author: Nafis Hasan, Aman Mann, Mauro Ferrari, Takemi Tanaka
https://pubs.acs.org/doi/abs/10.1021/nn204102q
The therapeutic potential of small interfering RNAs (siRNAs) is severely limited by the availability of delivery platforms that protect siRNA from degradation, deliver it to the target cell with high specificity and efficiency, and promote its endosomal escape and cytosolic dispersion. Here we report that mesoporous silica nanoparticle-supported lipid bilayers (or “protocells”) exhibit ...Author: Carlee E. Ashley, Eric C. Carnes, Katharine E. Epler, David P. Padilla, Genevieve K. Phillips, Rober...
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