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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202607/
May 01, 2010 · RNA interference (RNAi) is a powerful approach for silencing genes associated with a variety of pathologic conditions; however, in vivo RNAi delivery has remained a major challenge due to lack of safe, efficient, and sustained systemic delivery. Here, ...Author: Takemi Tanaka, Takemi Tanaka, Lingegowda S. Mangala, Pablo E. Vivas-Mejia, René Nieves-Alicea, Aman ...
https://cancerres.aacrjournals.org/content/70/9/3687
May 01, 2010 · RNA interference (RNAi) is a powerful approach for silencing genes associated with a variety of pathologic conditions; however, in vivo RNAi delivery has remained a major challenge due to lack of safe, efficient, and sustained systemic delivery. Here, we report on a novel approach to overcome these limitations using a multistage vector composed of mesoporous silicon particles (stage 1 ...Author: Takemi Tanaka, Takemi Tanaka, Lingegowda S. Mangala, Pablo E. Vivas-Mejia, René Nieves-Alicea, Aman ...
https://www.ncbi.nlm.nih.gov/pubmed/20430760
May 01, 2010 · Sustained small interfering RNA delivery by mesoporous silicon particles. Tanaka T(1), Mangala LS, Vivas-Mejia PE, Nieves-Alicea R, Mann AP, Mora E, Han HD, Shahzad MM, Liu X, Bhavane R, Gu J, Fakhoury JR, Chiappini C, Lu C, Matsuo K, Godin B, Stone RL, Nick AM, Lopez-Berestein G, Sood AK, Ferrari M.Author: Takemi Tanaka, Takemi Tanaka, Lingegowda S. Mangala, Pablo E. Vivas-Mejia, René Nieves-Alicea, Aman ...
https://www.researchgate.net/publication/43354714_Sustained_Small_Interfering_RNA_Delivery_by_Mesoporous_Silicon_Particles
A potential way of mitigating cancer is through RNA interference (RNAi) by the delivery of small interfering RNA (siRNA) to target select proteins or genes involved in cancer progression, known as ...
https://www.nature.com/articles/nplants2016207
Jan 09, 2017 · Topical application of pathogen-specific double-stranded RNA (dsRNA) for virus resistance in plants represents an attractive alternative to …Author: Neena Mitter, Elizabeth A. Worrall, Karl E. Robinson, Peng Li, Ritesh G. Jain, Christelle Taochy, St...
https://cancerres.aacrjournals.org/content/canres/70/9/3687.full-text.pdf
small interfering RNA (siRNA) delivery advantages they en-gender, nanoparticles also have some limitations including their potential for rapid clearance (10), instability in serum (11), and systemic toxicity, especially to the liver (3). More-over, most of the current RNAi delivery approaches require
https://etd.library.vanderbilt.edu/available/etd-10272011-113508/unrestricted/Nelson_Thesis.pdf
improving wound healing, but unfortunately cannot close 50% of chronic wounds [1]. Recently, small interfering RNA (siRNA) has been proposed as a potential treatment for a range of pathologies including skin wounds, and biomaterial scaffold-based siRNA delivery has been recently sought using both natural and synthetic scaffolds [2-5].
https://scholars.houstonmethodist.org/en/publications/sustained-small-interfering-rna-delivery-by-mesoporous-silicon-particles(a2cd7cf8-b0c7-4871-a11b-1a27f5255a2b).html
Takemi Tanaka, Lingegowda S. Mangala, Pablo E. Vivas-Mejia, René Nieves-Alicea, Aman P. Mann, Edna Mora, Hee Dong Han, Mian M.K. Shahzad, Xuewu Liu, Rohan Bhavane ...Author: Takemi Tanaka, Takemi Tanaka, Lingegowda S. Mangala, Pablo E. Vivas-Mejia, René Nieves-Alicea, Aman ...
https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.12703
Small interfering RNA (siRNA) targeting liver AGT (angiotensinogen) provides antihypertensive and cardioprotective efficacy comparable to that of single renin-angiotensin system blockade. Ang II (angiotensin II) elimination requires >99% suppression of circulating AGT, and under such circumstances, blood pressure decreases substantially.Author: Estrellita Uijl, Katrina M. Mirabito Colafella, Katrina M. Mirabito Colafella, Yuan Sun, Liwei Ren, ...
https://www.researchgate.net/publication/49855355_Localized_Targeted_and_Sustained_siRNA_Delivery
Request PDF Localized, Targeted, and Sustained siRNA Delivery Short interfering RNA (siRNA) functions directly in the cytoplasm, where it is assembled into an RNA-induced silencing complex (RISC).
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