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https://www.academia.edu/2472206/Targeted_drug_Delivery_to_Macrophages
Targeted drug Delivery to Macrophages
https://www.sciencedirect.com/science/article/pii/S0168365915302662
3. Macrophages in drug delivery 3.1. Macrophages as a target for drug delivery. Macrophages have long been an important target for drug delivery. For example, antibacterial agents are delivered to macrophages for the treatment of intracellular infections, such …Author: Yihua Pei, Yoon Yeo
https://www.researchgate.net/publication/234068265_Targeted_drug_delivery_to_macrophages
Thus, macrophages can be exploited as Trojan horses for targeted drug delivery. Nanocarriers can migrate across the different membrane barriers and release their drug cargo at sites of infection.
https://www.researchgate.net/publication/287390137_Drug_delivery_to_macrophages_Challenges_and_opportunities
Macrophages are prevalent in the body and have roles in almost every aspect of human biology. They have often been considered a subject to avoid during drug delivery.
https://www.sciencedirect.com/science/article/abs/pii/S0169409X1930239X
Here, we discuss the role of macrophages in the initiation and progression of various inflammatory diseases, summarize the leading drugs used to regulate macrophages, and review drug delivery systems designed to target macrophages. We emphasize strategies that are approved for clinical use or are poised for clinical investigation.Author: Wei He, Wei He, Wei He, Neha Kapate, Neha Kapate, Neha Kapate, C. Wyatt Shields, C. Wyatt Shields, S...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4950366/
Other drug delivery strategies that have been shown to inhibit the foreign body response to biomaterials include the delivery of a blocking antibody to interleukin-4 (IL4), a cytokine that mediates macrophage fusion into foreign body giant cells in vitro and in vivo, 39,40 although it is important to note that the role of IL4 in the foreign ...Author: Reham Garash, Anamika Bajpai, Brandon M Marcinkiewicz, Kara L Spiller
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355695/
Jan 25, 2019 · In this review we propose an alternative to the strategies/approaches used until now: a novel macrophage-mediated drug delivery method that more accurately fits the term “drug delivery,” via incorporation of both nanomedicine and cellular manipulation. Macrophages are highly mobile cells.Author: Johan Georg Visser, Anton Du Preez Van Staden, Carine Smith
https://www.frontiersin.org/articles/10.3389/fphar.2019.00022/full
Jan 25, 2019 · With the effectiveness of therapeutic agents ever decreasing and the increased incidence of multi-drug resistant pathogens, there is a clear need for administration of more potent, potentially more toxic, drugs. Alternatively, biopharmaceuticals may hold potential but require specialized protection from premature in vivo degradation. Thus, a paralleled need for specialized drug delivery ...Author: Johan Georg Visser, Anton Du Preez Van Staden, Carine Smith
https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201805557
Oct 11, 2018 · Macrophages hold great potential in cancer drug delivery because they can sense chemotactic cues and home to tumors with high efficiency. However, it remains a challenge to load large amounts of therapeutics into macrophages without compromising cell functions. This study reports a silica‐based drug nanocapsule approach to solve this issue.Author: Weizhong Zhang, Mengzhe Wang, Wei Tang, Ru Wen, Shiyi Zhou, Chaebin Lee, Hui Wang, Wen Jiang, Ian Mi...
http://researchpub.org/journal/bmbn/number/vol2-no1/vol2-no1-5.pdf
argeted drug delivery of the mononuclear-phagocytic system cells has been long time considered to be an attractive strategy of treatment of infectious disease produced by specific pathogenic microorganisms. This is due to the fact that macrophages and dendritic cells are the main or alternative
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