We have collected information about Drug Delivery To Lysosomes for you. Follow the links to find out details on Drug Delivery To Lysosomes.
https://www.ncbi.nlm.nih.gov/pubmed/28862054
Lysosomes are of particular interest for the design and delivery of pH-dependent pro-drugs, enhancing selectivity and developing strategies to inhibit drug degradation inside the cells. There is great potential to bring intracellular drug delivery and distribution using nanotherapeutic approaches to target lysosomes for therapeutic interventions.Author: Ankur Sharma, Kalpesh Vaghasiya, Eupa Ray, Rahul Kumar Verma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891137/
Mar 01, 2016 · Success of drug delivery using ADCs or ANPs is predictably dependent on robust endocytosis of the receptor-bound drug and trafficking from early endosomes to lysosomes, where drug conjugate undergoes cleavage or nanoparticles optimally release their cytotoxic drug cargo, followed by drug entry into the cytosol [3-5]. In normal cells ...Author: Srikumar M. Raja, Srikumar M. Raja, Swapnil S. Desale, Bhopal Mohapatra, Haitao Luan, Kruti Soni, Ji...
https://www.sciencedirect.com/science/article/pii/S0142961213012647
The effect of autophagy inhibitors on drug delivery using biodegradable polymer nanoparticles in cancer treatment. ... which are exposed to degradation by lysosomes in the endo-lysosome delivery system. ... Enhanced drug delivery by drug-loaded PLGA NPs combined with autophagy inhibitors.Author: Xudong Zhang, Yichen Dong, Xiaowei Zeng, Xin Liang, Xiaoming Li, Wei Tao, Hongbo Chen, Yuyang Jiang,...
https://www.sciencedirect.com/science/article/abs/pii/S0169409X99000654
Predictions of ease of permeation across lysosome membranes is of value when drug delivery strategies are contemplated that involve a drug-conjugate reaching the lysosome compartment and drug release there by the lysosomal enzymes.Author: John B Lloyd
https://www.researchgate.net/publication/264613524_A_Lysosome_-_Targeted_Drug_Delivery_System_Based_on_Sorbitol_Backbone_towards_Efficient_Cancer_Therapy
A straightforward synthetic approach was adopted for the construction of a lysosome-targeted drug delivery system (TDDS) using sorbitol scaffold (Sor) linked to octa-guanidine and tetrapeptide ...
https://link.springer.com/article/10.1007/s40820-019-0310-0
Sep 25, 2019 · Nanosized cytotoxic drug could combat against the autophagy induced by the drug. The drug nanorods enabled efficient intracellular delivery of the nucleic acid and the resultant autophagy inhibition in vitro and in vivo, which in turn sensitized the cancer cells to the anti-tumor nanorods.Author: Xiaofei Xin, Xiaoqing Du, Qingqing Xiao, Helena S. Azevedo, Wei He, Lifang Yin
http://www.authorstream.com/Presentation/phani.thanneru-1598552-drug-delivery-lysosomal-storage-diseases/
Drug Delivery to Lysosomal Storage Diseases - authorSTREAM Presentation. Slide 18: Enzyme Delivery across the Blood-Brain Barrier(BBB): 1.BBB is characterized by a layer endothelial cells, joined by tight junction 2. this restricts transport of bulk recombinant enzymes across brain Methods used to by pass the barrier are 1 .opening BBB by infusion of hypo osmotic solution (arabinose) into the ...
https://www.omicsonline.org/open-access/liposomes-for-drug-delivery-2155-952X276-97370.html
Drug encapsulation in a liposomal or lipid drug delivery system improves the pharmacokinetic and pharmacodynamic properties to such an extent that the drugs can be brought into regular use . Advantages of liposomes as a drug delivery system for antimicrobials are: • Improvement and control over pharmacokinetics and pharmacodynamicsAuthor: Durgavati Yadav, Kumar Sandeep, Deepak Pandey, Ranu Kumari Dutta
https://www.nature.com/articles/s41573-019-0036-1
Sep 02, 2019 · Lysosomes are membrane-bound organelles with roles in processes involved in degrading and recycling cellular waste, cellular signalling and energy metabolism. Defects in genes encoding lysosomal ...Author: Srinivasa Reddy Bonam, Fengjuan Wang, Sylviane Muller
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