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The Staccato OBT system comprises the rapid vaporization of an excipient-free drug to form aerosol particles optimal for systemic delivery through inhalation. These aerosol particles are rapidly absorbed, resulting in peak plasma blood levels obtained in the first few minutes after administration.
https://engagetherapeutics.com/staccato-alprazolam/
Staccato Alprazolam (STAP-001) is a single-use, hand-held, drug-device combination product that provides rapid systemic delivery by inhalation of a thermally generated aerosol of alprazolam. STAP-001 represents a new dosage form for alprazolam and is based on the proprietary Staccato delivery system developed by Alexza Pharmaceuticals.
http://www.alexza.com/pipeline/
Staccato fentanyl is the investigational combination of Alexza’s proprietary Staccato system with fentanyl, a drug belonging to the class of compounds known as opioid analgesics. Specifically, Staccato fentanyl is a handheld, multi-dose inhaler designed to generate and deliver excipient-free fentanyl aerosol for deep lung delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334339/
Feb 12, 2015 · The STACCATO ® is a novel breath-actuated inhalation delivery system, which uses heat to vaporize a thin film of the drug, which later condenses in the lungs into droplets or particles depending on the nature of the drug.78 In that case, the drug is dissolved in volatile solvent/solvent mixture which is sprayed over a metal substrate such as zinc halides. The best drug candidates for …Author: Mariam Ibrahim, Rahul Verma, Lucila Garcia-Contreras
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326558/
Alexza Pharmaceutical’s Staccato ® technology is a novel inhalation drug delivery system. The Staccato ® system consists of a breath-actuated inhaler that incorporates a solid, thin film of drug on an inert metal substrate. By rapidly heating the metal substrate, the drug film is rapidly vaporized to form a highly pure aerosol.Author: Chad J. Reissig, Joseph A. Harrison, Lawrence P. Carter, Roland R. Griffiths
https://www.fiercebiotech.com/regulatory/u-s-fda-approves-alexza-s-adasuve%C2%AE-loxapine-inhalation-powder-for-acute-treatment-of
Dec 24, 2012 · The Staccato system is a hand-held inhaler that delivers a drug aerosol to the deep lung that results in rapid systemic delivery and absorption of a drug. See below for Important Safety ...
https://www.sciencedirect.com/science/article/pii/S1471489217300176
Inhaler systems for delivery of complex drugs. For successful drug delivery by inhalation, formulation into an appropriate inhalable form with sufficient stability and aerodynamic properties is critical . Drug molecules are either dissolved or suspended in a liquid or formulated into a dry powder, and then inhaled using pressurised metered dose inhalers (pMDIs), liquid inhalers including (jet and ultrasonic) …Author: Wilbur de Kruijf, Carsten Ehrhardt
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113625/
Apr 12, 2014 · The Staccato® device is a single dose, disposable unit that utilizes a unique thermal system to rapidly heat and vaporize a thin film of drug (72). As the patient inhales, the vapor condenses to form pure drug particles that deposit in the alveolar regions for swift systemic absorption.Author: John Gar Yan Chan, Jennifer Wong, Qi Tony Zhou, Sharon Shui Yee Leung, Hak-Kim Chan
Alexza’s products and development pipeline are based on the Staccato ® One Breath Technology™ – OBT™ system, a handheld inhaler designed to deliver a pure drug aerosol to the deep lung, providing rapid systemic delivery and therapeutic onset in a simple, non-invasive manner.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4444630/
May 12, 2015 · The Breezhaler, marketed as Neohaler™ in the USA, has been developed by Novartis (Basel, Switzerland), and is approved for the delivery of indacaterol (a long-acting β-adrenergic drug) and glycopyrronium bromide (an anticholinergic drug), both indicated for the treatment of COPD.Author: Kai Berkenfeld, Alf Lamprecht, Jason T. McConville
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