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The Staccato OBT system comprises the rapid vaporization of an excipient-free drug to form aerosol particles optimal for systemic delivery through inhalation. These aerosol particles are rapidly absorbed, resulting in peak plasma blood levels obtained in the first few minutes after administration.
https://engagetherapeutics.com/staccato-alprazolam/
The Staccato delivery system is user-friendly and easy to use. Device actuation, aerosol formation, and delivery of the aerosolized drug to the deep lung are all accomplished with a …
http://www.alexza.com/pipeline/
Staccato fentanyl is the investigational combination of Alexza’s proprietary Staccato system with fentanyl, a drug belonging to the class of compounds known as opioid analgesics. Specifically, Staccato fentanyl is a handheld, multi-dose inhaler designed to generate and deliver excipient-free fentanyl aerosol for deep lung delivery.
https://www.fiercepharma.com/pharma/alexza-pharmaceuticals-staccato%C2%AE-technology-receives-frost-sullivan-enabling-technology
Alexza's technology, the Staccato ® system, vaporizes unformulated drug to form a condensation aerosol that, when inhaled, allows for rapid systemic drug delivery through deep lung inhalation.
https://www.fiercebiotech.com/regulatory/u-s-fda-approves-alexza-s-adasuve%C2%AE-loxapine-inhalation-powder-for-acute-treatment-of
Dec 24, 2012 · The Staccato system is a hand-held inhaler that delivers a drug aerosol to the deep lung that results in rapid systemic delivery and absorption of a drug. See below for Important Safety ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334339/
Feb 12, 2015 · The STACCATO ® is a novel breath-actuated inhalation delivery system, which uses heat to vaporize a thin film of the drug, which later condenses in the lungs into droplets or particles depending on the nature of the drug.78 In that case, the drug is dissolved in volatile solvent/solvent mixture which is sprayed over a metal substrate such as zinc halides. The best drug candidates for such systems …Author: Mariam Ibrahim, Rahul Verma, Lucila Garcia-Contreras
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113625/
Apr 12, 2014 · The Staccato® device is a single dose, disposable unit that utilizes a unique thermal system to rapidly heat and vaporize a thin film of drug (72). As the patient inhales, the vapor condenses to form pure drug particles that deposit in the alveolar regions for swift systemic absorption.Author: John Gar Yan Chan, Jennifer Wong, Qi Tony Zhou, Sharon Shui Yee Leung, Hak-Kim Chan
https://www.researchgate.net/publication/280639855_New_Approaches_to_Psychotic_Agitation_Staccato_Loxapine
Inhaled loxapine is delivered by a hand-held, single-dose, single-use device that uses the Staccato(®) drug delivery system.
https://www.sciencedirect.com/science/article/pii/S1471489217300176
Inhaler systems for delivery of complex drugs. For successful drug delivery by inhalation, formulation into an appropriate inhalable form with sufficient stability and aerodynamic properties is critical . Drug molecules are either dissolved or suspended in a liquid or formulated into a dry powder, and then inhaled using pressurised metered dose ...Author: Wilbur de Kruijf, Carsten Ehrhardt
https://www.nibib.nih.gov/science-education/science-topics/drug-delivery-systems-getting-drugs-their-targets-controlled-manner
Drug delivery systems are engineered technologies for the targeted delivery and/or controlled release of therapeutic agents. Drugs have long been used to improve health and extend lives. The practice of drug delivery has changed dramatically in the past few decades and even greater changes are anticipated in the near future.
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