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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · The selection of siRNA delivery systems depends on the properties of siRNA, the type of target cells, and the delivery routes for in vivo application. Fig. 3. Examples of siRNA delivery carriers. a siRNA bioconjugates: siRNA is conjugated with selected molecules through …Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.nature.com/articles/nmat3765
Oct 23, 2013 · This Review discusses the biological challenges that siRNA delivery materials aim to overcome, as well as the most clinically advanced classes …Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson
http://altogenlabs.com/rna-interference-rnai-services/in-vivo-sirna-delivery-and-tissue-targeting/
In Vivo siRNA Delivery and Tissue Targeting. RNAi-induced gene silencing is used to study gene function in cultured cells (in vitro). Most often, these effects are induced by the introduction of small-interfering RNA (siRNA) or microRNA (miRNA). A siRNA molecule is double-stranded and 20-24 base pairs in length, terminating in two overhanging ...
https://www.sigmaaldrich.com/technical-documents/articles/biology/sirna-difficult-cells.html
The siRNA is a 19- to 25-bp dsRNA that can activate the RISC enzyme. The crucial factor in using siRNA is the successful delivery of the siRNA oligonucleotides to cultured cells. The siRNAs are often delivered into cells using transfection reagents; however, efficient siRNA delivery is difficult in some cell lines.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160355/
Aug 30, 2014 · In regards to siRNA delivery, five papers are discussed here that are mostly interested in identifying novel targets that can be therapeutically downregulated to reduce the secretion of pro-inflammatory cytokines. Peptides , polymers , viruses , even free nucleic acids [37, 143] have been used to achieve this effect. The results obtained with ...Author: Olivia M. Merkel, Israel Rubinstein, Thomas Kissel
https://www.sciencedirect.com/science/article/pii/S0169409X19300547
This was an important milestone for the field of siRNA delivery that opens the door for additional siRNA drugs. Currently, >20 small interfering RNA (siRNA)-based therapies are in clinical trials for a wide variety of diseases including cancers, genetic disorders, and viral infections. To maximize therapeutic benefits of siRNA-based drugs, a ...Author: Yizhou Dong, Daniel J. Siegwart, Daniel G. Anderson
https://www.nature.com/articles/ncomms5277
Jun 27, 2014 · In vitro screening of LNPs for siRNA delivery. Before testing the transfection ability of lipidoids, they were first formulated into LNPs containing siRNA and the helper lipids cholesterol, 1,2 ...Author: Kathryn A. Whitehead, Kathryn A. Whitehead, J Robert Dorkin, Arturo J. Vegas, Philip H. Chang, Omid ...
https://www.sciencedirect.com/science/article/pii/S1818087614000646
If siRNA delivery provokes unacceptable toxicity on either a cellular or systemic level, even the most efficacious siRNA delivery system will be rendered useless. Viral vectors, which were among the first vehicles to be studied for siRNA delivery, can induce unacceptable levels of toxicity through the activation of immune responses [38] .Author: Cong-fei Xu, Jun Wang
https://www.researchgate.net/publication/336161535_Rekindling_RNAi_Therapy_Materials_Design_Requirements_for_In_Vivo_siRNA_Delivery
for delivery of siRNA, such as those against PLK-1 (TKM-080301) for the treatment of neuroendocrine tumors (NET), adrenocor - tical carcinoma (ACC), and primary/secondary liver cancer.
https://pubs.acs.org/doi/abs/10.1021/jacs.5b03429
Aerosol delivery of stabilized polyester-siRNA nanoparticles to silence gene expression in orthotopic lung tumors. Biomaterials 2017 , 118 , 84-93. DOI: 10.1016/j.biomaterials.2016.12.001.Author: Jing Hao, Petra Kos, Kejin Zhou, Jason B. Miller, Lian Xue, Yunfeng Yan, Hu Xiong, Sussana Elkassih,...
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