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https://pubs.acs.org/doi/10.1021/bc800278e
Nov 17, 2008 · Small interfering RNA (siRNA) has been chemically conjugated to a variety of bioactive molecules, lipids, polymers, peptides, and inorganic nanostructured materials to enhance their pharmacokinetic behavior, cellular uptake, target specificity, and safety. To efficiently deliver siRNAs to the target cells and tissues, many different siRNA bioconjugates were synthesized and characterized, …Author: Ji Hoon Jeong, Hyejung Mok, Yu-Kyoung Oh, Tae Gwan Park
http://pubs.acs.org/doi/abs/10.1021/bc800278e
Small interfering RNA (siRNA) has been chemically conjugated to a variety of bioactive molecules, lipids, polymers, peptides, and inorganic nanostructured materials to enhance their pharmacokinetic behavior, cellular uptake, target specificity, and safety. To efficiently deliver siRNAs to the target cells and tissues, many different siRNA bioconjugates were synthesized and characterized, and ...
https://www.sciencedirect.com/science/article/pii/S1818087614000646
The currently developed siRNA delivery systems for cancer therapy can be divided into four categories: chemical modifications, lipid-based nanovectors, polymer-mediated delivery systems, conjugate delivery systems, and others (exosomes, RNAi-microsponges, oligonucleotide nanoparticles). 4.1. Chemical modifications of anti-cancer siRNAAuthor: Cong-fei Xu, Jun Wang
https://www.sciencedirect.com/science/article/pii/S0169409X19300547
A few polymer-based siRNA delivery systems have shown therapeutic potential in clinical trials . Examples of major classes of polymer-based delivery systems are discussed below. 7. siRNA-polymer bioconjugates. Direct conjugation of siRNA to polymers offers an attractive avenue to improve stability, pharmacokinetics, cellular uptake, and delivery.Author: Yizhou Dong, Daniel J. Siegwart, Daniel G. Anderson
https://www.researchgate.net/publication/23568255_siRNA_Conjugate_Delivery_Systems
Conjugate siRNA delivery system for cancer therapy A common approach for targeted delivery of siRNA to specific cells or tissues is conjugation to deliver materials such as functional peptides ...
https://www.academia.edu/5121917/siRNA_Conjugate_Delivery_Systems
siRNA Conjugate Delivery Systems
https://www.nature.com/articles/nmat3765
Oct 23, 2013 · This Review discusses the biological challenges that siRNA delivery materials aim to overcome, as well as the most clinically advanced classes of siRNA delivery …Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · The selection of siRNA delivery systems depends on the properties of siRNA, the type of target cells, and the delivery routes for in vivo application. ... The cholesterol–siRNA conjugate showed greater stability and, upon intravenous injection, was detected in the liver, heart, lungs, kidneys, ...Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631009/
Jun 13, 2019 · In this review, we focus on the current aspects of various siRNA conjugate delivery systems that have potential to open new avenues for clinical utility. Advances in chemical conjugation on siRNA backbone have been reviewed elsewhere . 2. The siRNA Conjugation Strategy. 2.1. Structural Diversity of the siRNA DuplexAuthor: Wanyi Tai
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