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https://www.nature.com/articles/nrn2205
Aug 01, 2007 · For the in vivo examination of siRNA delivery, mice were intravenously injected with a fluorescent siRNA–RVG–9R peptide complex. The uptake of the siRNA was strictly brain specific, and no ...Author: Alexandra Flemming
https://www.nature.com/articles/nrd2386
Aug 01, 2007 · For the in vivo examination of siRNA delivery, mice were intravenously injected with a fluorescent siRNA–RVG–9R peptide complex. The uptake of the siRNA was strictly brain specific, and no fluorescence was detected in the liver or spleen. Microscopic examination of brain sections confirmed fluorescence throughout the brain.Author: Alexandra Flemming
http://www.signaling-gateway.org/update/updates/200708/nrn2205.html
A new technique enables the targeted delivery of small interfering RNA (siRNA) molecules across the blood brain barrier to the central nervous system, permitting gene-by-gene analysis of brain function and validation of therapeutic targets.
https://zon.trilinkbiotech.com/2019/11/12/doubling-down-on-sirnas-in-the-brain/
Nov 12, 2019 · Novel “Di-siRNA” Compound Affords Long-Lasting Gene Silencing in the Brain A Single Injection Leads to Gene Silencing for at Least One Month! Cooperativity of Phosphorothioate Linkages is Key for this Breakthrough Anatomically accurate illustration of the human brain.
https://www.researchgate.net/publication/247443428_Drug_techniques_siRNA_Brain_delivery_breakthrough
Request PDF Drug techniques: siRNA: Brain delivery breakthrough A key challenge in the development of drugs for CNS diseases is their transport across the blood–brain barrier (BBB).Author: Alexandra Flemming
https://www.researchgate.net/publication/241606893_Drug_deliverysiRNA_brain_delivery_breakthrough
Reporting in Nature, Kumar and colleagues have now developed a method to target small-interfering RNA (siRNA) to the CNS, providing a safe and non-invasive approach for the delivery of this new ...Author: Alexandra Flemming
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
In fact, in the single clinical trial reported for RNAi delivery to brain tumor (which targeted tenancin-C), the siRNA was injected directly into infiltrative (inoperable) regions of brain tumor . Steady progress in tissue-targeting methods has enabled researchers to deliver siRNA to diseased tissues or organs via the systemic route with positive outcomes, including the brain.Author: Saroj P Mathupala
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572210/
Mar 30, 2007 · The delivery of siRNA to brain is analogous to the delivery of antisense agents such as PNAs to brain. The studies reviewed in Figs. 6 and and7 7 demonstrate the delivery of PNA antisense agents to brain in vivo [ 43 ]. siRNA duplexes can be monobiotinylated [ 52 ], which allows for high efficiency attachment to molecular Trojan horses using avidin-biotin technology.Author: William M. Pardridge
https://pubs.acs.org/doi/abs/10.1021/acsnano.6b03858
Abstract. Traumatic brain injuries (TBIs) affect 2.5 million Americans per year, and survivors of TBI can develop long-term impairments in physical, cognitive, and psychosocial functions. Currently, there are no treatments available to stop the long-term effects of TBI. Although the primary injury can only be …Author: Ester J. Kwon, Matthew Skalak, Riana Lo Bu, Sangeeta N. Bhatia
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