We have collected information about Sirna Brain Delivery for you. Follow the links to find out details on Sirna Brain Delivery.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
The study demonstrates the efficacy of CPP conjugated siRNA duplexes in targeting primary neurons in vitro and the CNS tissue in vivo (however, this is via invasive administration of the siRNA directly to the brain tissue by convection enhanced delivery). The approach has minimal toxicity towards the targeted cells, in contrast to reported ...Author: Saroj P Mathupala
https://www.ncbi.nlm.nih.gov/pubmed/21423189
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Alvarez-Erviti L(1), Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Author information: (1)Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · Delivery of therapeutic siRNA to specific tissues is a major challenge. Alvarez-Erviti et al. show that exosomes—small vesicles that are naturally secreted by many animal cells—can be ...Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.sciencedirect.com/science/article/pii/S0142961213009848
The goal of the present study was to develop a novel, efficient brain delivery system composed of nucleic acids, such as siRNA. Therefore, we evaluated the delivery of siRNA to the brain following i.n. administration with a MPEG–PCL–Tat carrier.Author: T. Kanazawa, F. Akiyama, S. Kakizaki, Y. Takashima, Y. Seta
https://pubs.acs.org/doi/abs/10.1021/acsnano.6b03858
Traumatic brain injuries (TBIs) affect 2.5 million Americans per year, and survivors of TBI can develop long-term impairments in physical, cognitive, and psychosocial functions. Currently, there are no treatments available to stop the long-term effects of TBI. Although the primary injury can only be prevented, there is an opportunity for intervention during the secondary injury, which persists ...Author: Ester J. Kwon, Matthew Skalak, Riana Lo Bu, Sangeeta N. Bhatia
https://www.nature.com/articles/nrn2205
Aug 01, 2007 · siRNA: brain delivery breakthrough. For the in vivo examination of siRNA delivery, mice were intravenously injected with a fluorescent siRNA–RVG–9R peptide complex. The uptake of …Author: Alexandra Flemming
https://www.sciencedirect.com/science/article/pii/S0169409X07000221
The delivery of siRNA to brain is analogous to the delivery of antisense agents such as PNAs to brain. The studies reviewed in Fig. 6, Fig. 7 demonstrate the delivery of PNA antisense agents to brain in vivo . siRNA duplexes can be monobiotinylated , which allows for high efficiency attachment to molecular Trojan horses using avidin–biotin ...Author: William M. Pardridge
https://www.researchgate.net/profile/Haifang_Yin/publication/50596721_Alvarez-Erviti_L_Seow_Y_Yin_H_Betts_C_Lakhal_S_and_Wood_MJA_Delivery_of_siRNA_to_the_mouse_brain_by_systemic_injection_of_targeted_exosomes_Nat_Biotechnol_29_341-345/links/0fcfd507cae85f1a2e000000/Alvarez-Erviti-L-Seow-Y-Yin-H-Betts-C-Lakhal-S-and-Wood-MJA-Delivery-of-siRNA-to-the-mouse-brain-by-systemic-injection-of-targeted-exosomes-Nat-Biotechnol-29-341-345.pdf
Delivery of sirNA to the mouse brain by systemic injection of targeted exosomes. Lydia Alvarez-Erviti. 1,2, Yiqi Seow. 1,2, HaiFang Yin , Corinne Betts , Samira Lakhal. 1 & Matthew J A Wood. 1.
https://www.researchgate.net/profile/Bingyang_Shi/publication/322979245_Nanotechnology-Based_Strategies_for_siRNA_Brain_Delivery_for_Disease_Therapy/links/5c639647299bf1d14cc2026b/Nanotechnology-Based-Strategies-for-siRNA-Brain-Delivery-for-Disease-Therapy.pdf
Review Nanotechnology-Based Strategies for siRNA Brain Delivery for Disease Therapy Meng Zheng,1 Wei Tao,2 Yan Zou,1 Omid C. Farokhzad,2 and Bingyang Shi1,* Small interfering RNA (siRNA)-based ...
https://www.hindawi.com/journals/jphar/2013/812387/
The siRNA delivery was found to be significant in cerebral cortex and cerebellum after 4 hrs of intranasal postdelivery. Furthermore, the biodistribution and toxicity characterization demonstrated maximum siRNA delivery in the brain with no visible, local toxic effects linked to delivery of …Author: Meenakshi Malhotra, Catherine Tomaro-Duchesneau, Shyamali Saha, Satya Prakash
Searching for Sirna Brain Delivery?
You can just click the links above. The data is collected for you.
