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https://www.sciencedirect.com/science/article/pii/S1818087614000646
The attitude of big pharmaceutical companies to RNAi drugs has also become over-optimistic. In summary, a good delivery system is the key to siRNA drug development. Once research into siRNA drug delivery systems makes a significant breakthrough, siRNA will occupy a strong position in the drug market, especially the anti-cancer drug market.Author: Cong-fei Xu, Jun Wang
https://www.nature.com/articles/s41573-019-0017-4
Mar 07, 2019 · The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all human cells. Small double-stranded RNA molecules can …Author: Ryan L. Setten, Ryan L. Setten, John J. Rossi, John J. Rossi, Si-ping Han, Si-ping Han
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-017-0450-0
Jun 27, 2017 · Delivery materials. Broadly speaking, RNA delivery can be mediated by viral and non-viral vectors. For viral RNA delivery, there has been a great deal of interest in engineering adeno-associated viruses to carry nucleic acid cargo []—however, this section will focus mainly on the development of non-viral materials (Table 1).Of the non-viral RNA delivery vehicles, nanoparticles are perhaps ...Author: James C. Kaczmarek, Piotr S. Kowalski, Daniel G. Anderson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · The site of action of siRNA therapeutics is the cytosol. The barriers to siRNA delivery are multiple and depend on the targeted organs and the administration routes. In general, locoregional delivery of siRNA has fewer barriers compared to systemic delivery.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.mdpi.com/1999-4923/12/2/178/pdf
This Special Issue of Pharmaceutics titled “Drug Delivery of siRNA Therapeutics” aims to present the state of the art of siRNA delivery, embracing investigation strategies of international research groups with di erent experiences and skills. The Special Issue will thus be devoted to presentingAuthor: Gaetano Lamberti, Anna Angela Barba
https://www.sciencedirect.com/science/article/pii/S1549963408000828
Drug delivery of siRNA therapeutics: potentials and limits of nanosystems. ... Current CPP-mediated siRNA delivery approaches can be divided in two main categories: noncovalent CPP-siRNA in complex by virtue of electrostatic interactions, and CPPs covalently attached to siRNA duplexes through disulfide bond formations. ... Many studies on ...Author: Daniela Reischl, Andreas Zimmer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3816686/
The flow cytometry data representing the efficiency of the polymer for siRNA-drug co-delivery are also shown. This study clearly demonstrated that lipid modification enhances the cellular association of the nanocarrier without compromising the siRNA condensation ability of the dendrimers.Author: Swati Biswas, Vladimir P. Torchilin
https://www.mdpi.com/journal/pharmaceutics/special_issues/drug_delivery_of_siRNA_therapeutics
After a brief description of OC and siRNA features, we summarized the strategies employed to minimize siRNA delivery problems, the targeting strategies to OC, and the preclinical models available. Finally, we discussed the most interesting works published in the last three years about polymer-/lipid-based materials for siRNA delivery. Full article
https://www.biologicsblog.com/fda-approves-first-ever-sirna-therapy/
Aug 10, 2018 · Today FDA approved the first-ever “small interfering RNA” (siRNA) product, marking a significant milestone in the story of RNA interference (RNAi) technology and clearing the way for a new type of therapeutic. Alnylam® secured approval and Orphan Drug Designation for its siRNA product Onpattro (patisiran), a therapy for the rare hereditary disease transthyretin-mediated amyloidosis in ...
https://phys.org/news/2018-08-rna-drug.html
Aug 17, 2018 · The Food and Drug Administration recently approved the very first therapeutic small interfering RNA (siRNA), ... To improve the delivery of the drug to …Author: Thomas Schmittgen
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