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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2977003/
Jun 11, 2010 · Lipid-based siRNA delivery systems include liposomes, micelles, microemulsions, and solid lipid nanoparticles . Liposomes are globular vesicles with an aqueous core and phospholipid bilayer, comprise natural body constituents (e.g., lipids, sterols), and are biocompatible and biodegradable.Author: Jie Wang, Ze Lu, M. Guillaume Wientjes, Jessie L.-S. Au
https://www.nature.com/articles/nmat3765
Oct 23, 2013 · RNA interference (RNAi) has broad potential as a therapeutic to reversibly silence any gene. To achieve the clinical potential of RNAi, delivery materials are required to transport short...Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542916/
Mar 30, 2017 · Polymer- mediated Delivery Systems. For siRNA delivery, Polymers have emerged as an alternative class of extensively investigated carriers [71, 72]. Polymer-based delivery systems have been extensively used for plasmid DNA and more recently for siRNA [73-75]. As non-viral siRNA and plasmid vectors, many polymers have been thoroughly investigated because of their physical …Author: Hassan Dana, Ghanbar Mahmoodi Chalbatani, Habibollah Mahmoodzadeh, Rezvan Karimloo, Omid Rezaiean, A...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6631009/
Jun 13, 2019 · Studies on siRNA delivery have seen intense growth in the past decades since siRNA has emerged as a new class of gene therapeutics for the treatment of various diseases. siRNA bioconjugate, as one of the major delivery strategies, offers the potential to enhance and broaden pharmacological properties of siRNA, while minimizing the heterogeneity and stability-correlated …Author: Wanyi Tai
https://www.nature.com/articles/nprot.2012.131
Nov 15, 2012 · The use of small interfering RNAs (siRNAs) to induce gene silencing has opened a new avenue in drug discovery. However, their therapeutic potential is hampered by …Author: Samir El-Andaloussi, Samir El-Andaloussi, Yi Lee, Samira Lakhal-Littleton, Jinghuan Li, Yiqi Seow, C...
https://www.sciencedirect.com/science/article/pii/S0169409X09000969
The spatial and temporal distribution of siRNA within the cell is in accord with the observed kinetics of siRNA mediated RNA interference activity which peaks around 24 h post delivery …Author: Donald D. Rao, John S. Vorhies, Neil Senzer, John Nemunaitis
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