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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3572210/
Mar 30, 2007 · The delivery of siRNA to brain is analogous to the delivery of antisense agents such as PNAs to brain. The studies reviewed in Figs. 6 and and7 7 demonstrate the delivery of PNA antisense agents to brain in vivo [ 43 ]. siRNA duplexes can be monobiotinylated [ 52 ], which allows for high efficiency attachment to molecular Trojan horses using avidin-biotin technology.Author: William M. Pardridge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698461/
In fact, in the single clinical trial reported for RNAi delivery to brain tumor (which targeted tenancin-C), the siRNA was injected directly into infiltrative (inoperable) regions of brain tumor . Steady progress in tissue-targeting methods has enabled researchers to deliver siRNA to diseased tissues or organs via the systemic route with positive outcomes, including the brain.Author: Saroj P Mathupala
https://www.nature.com/articles/nrn2205
Aug 01, 2007 · For the in vivo examination of siRNA delivery, mice were intravenously injected with a fluorescent siRNA–RVG–9R peptide complex. The uptake of the siRNA was strictly brain …Author: Alexandra Flemming
https://www.nature.com/articles/nbt.1807
Mar 20, 2011 · Intravenously injected RVG-targeted exosomes delivered GAPDH siRNA specifically to neurons, microglia, oligodendrocytes in the brain, resulting in a specific gene knockdown.Author: Lydia Alvarez-Erviti, Yiqi Seow, HaiFang Yin, Corinne Betts, Samira Lakhal, Matthew J A Wood
https://www.ncbi.nlm.nih.gov/pubmed/29422412
However, effective and safe systemic delivery of siRNA into the brain remains challenging because of biological barriers such as enzymatic degradation, short circulation lifetime, the blood-brain barrier (BBB), insufficient tissue penetration, cell endocytosis, and cytosolic transport.Author: Meng Zheng, Wei Tao, Yan Zou, Omid C. Farokhzad, Bingyang Shi
https://www.sciencedirect.com/science/article/pii/S0169409X07000221
The delivery of siRNA to brain is analogous to the delivery of antisense agents such as PNAs to brain. The studies reviewed in Fig. 6 , Fig. 7 demonstrate the delivery of PNA antisense agents to brain in vivo [43] . siRNA duplexes can be monobiotinylated [52] , which allows for high efficiency attachment to molecular Trojan horses using avidin–biotin technology.Author: William M. Pardridge
https://www.sciencedirect.com/science/article/pii/S0142961213009848
In this study, we describe intranasal brain delivery of siRNA or dextran (Mw: 10,000 Da) as a model siRNA, by using MPEG–PCL–Tat. Intranasal delivery of dextran with MPEG–PCL–Tat improved brain delivery compared to intravenous delivery of dextran either with or without MPEG–PCL–Tat.Author: T. Kanazawa, F. Akiyama, S. Kakizaki, Y. Takashima, Y. Seta
https://pubs.acs.org/doi/abs/10.1021/acsnano.6b03858
We engineered a neuron-targeting nanoparticle which can mediate intracellular trafficking of siRNA cargo and achieve silencing of mRNA and protein levels in cultured cells. We hypothesized that, soon after an injury, nanoparticles in the bloodstream may be able to infiltrate brain tis...Author: Ester J. Kwon, Matthew Skalak, Riana Lo Bu, Sangeeta N. Bhatia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204174/
Aug 11, 2014 · We have used α-Syn small interfering RNA (siRNA) to reduce total and aggregated α-Syn levels in mouse brains. To achieve widespread delivery of siRNAs to the brain we have peripherally injected modified exosomes expressing Ravies virus glycoprotein loaded with siRNA. Normal mice were analyzed 3 or 7 days after injection.Author: JM Cooper, PB Wiklander, JZ Nordin, R Al-Shawi, MJ Wood, M Vithlani, AH Schapira, JP Simons, S El-An...
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