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https://www.alnylam.com/our-science/the-science-of-rnai/
The Science of RNA i. RNAi: A Revolution in Biology Built on Nobel Prize-Winning Research ... and is mediated by small interfering RNA (siRNA) molecules. By harnessing this natural biologic pathway, RNAi therapeutics can be readily designed to be highly selective. ... Finally, approaches for delivery of investigational RNAi therapeutics have ...
https://www.alnylam.com/our-science/
Science That Can Change the World. The discovery of RNA interference (RNAi) has been heralded as a major scientific breakthrough of the kind that happens only once every decade or so, and it represents one of the most promising and rapidly advancing frontiers in biology and drug discovery today.
https://www.nasdaq.com/articles/alnylam-vir-collaborate-on-rnai-therapy-for-coronavirus-2020-03-05
Mar 05, 2020 · Going by the agreement, the companies will leverage Alnylam’s recent advances in lung delivery of novel conjugates of siRNA along with Vir’s expertise in infectious disease and established...
https://www.alnylam.com/2019/06/21/new-rnai-platform-advances-including-oral-route-of-administration-and-cns-and-ocular-delivery/
Jun 21, 2019 · These new preclinical data are the first demonstration of functional delivery of GalNAc-siRNA conjugates via the oral route of administration, representing an important step forward in potentially advancing and expanding the clinical and commercial potential of RNAi therapeutics. ... Alnylam Pharmaceuticals does not endorse and is not ...
https://www.alnylam.com/2019/03/29/pre-clinical-data-delivery-rnai-therapeutics-cns-eye/
Mar 29, 2019 · With regard to ocular delivery, a single intravitreal injection of an siRNA conjugate targeting TTR in rats and NHPs led to potent and durable silencing in the eye. RNAi therapeutics directed to disease-causing, CNS- or ocular-expressed genes represent a potential opportunity to address devastating diseases with enormous burden and unmet need.
https://wxpress.wuxiapptec.com/tackling-covid-19-at-a-potential-achilles-heel-sirna-a-conversation-with-alnylams-ceo-john-maraganore/
Apr 08, 2020 · Alnylam and Vir Biotechnology expanded their 2017 partnership earlier this month – leveraging Alnylam’s lung delivery technology of novel conjugates of siRNA with Vir’s expertise and extensive capabilities in infectious disease – to target […]
https://www.alnylam.com/2018/05/08/new-preclinical-data-demonstrating-cns-delivery-of-rnai-therapeutics/
The novel siRNA conjugates utilize Alnylam’s enhanced stabilization chemistry (ESC) platform with further modifications to enable broad CNS delivery and efficient uptake in neuronal cells.
https://www.alnylam.com/alnylam-rnai-pipeline/
Learn about Alnylam's pipeline of investigational RNAi therapeutics and how the company is leading the translation of RNAi into a new class of innovative medicines to treat a variety of conditions.
https://www.alnylam.com/alnylam-rnai-pipeline/clinical-trials/
Our Clinical Trials. Alnylam is committed to developing new, innovative medicines to treat diseases with high unmet medical need. A clinical trial involves research using human volunteers (trial participants, including healthy volunteers or patients), and is intended to answer specific questions about potential new treatments for certain diseases.
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