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http://pubs.acs.org/doi/abs/10.1021/ar300048p
Since 2007, she has been a Ph.D. student at the Center for Neuroscience and Cell Biology (CNC) of the University of Coimbra, where she has been developing lipid-based nanoparticles for the targeted systemic delivery of nucleic acids towards solid tumors.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618487/
Mar 25, 2015 · Also, the nanoparticles can also be used for the co-delivery of c-Myc siRNA and doxorubicin. Because of the high biocompatibility of lipid-based nanocarriers with normal tissues, there are studies to explore the use of this class of RNA delivery platforms for non-cancer diseases.Author: Hui Yi Xue, Pengbo Guo, Wu-Cheng Wen, Ho Lun Wong
https://pubs.acs.org/doi/10.1021/ar300048p
In this regard, major advances have been achieved with lipid-based nanocarriers sterically stabilized by poly(ethylene glycol) (PEG), such as the stabilized nucleic acid lipid particles (SNALP). However, PEG has not solved all the major problems associated with siRNA delivery.Author: Lígia C. Gomes-da-Silva, Nuno A. Fonseca, Vera Moura, Maria C. Pedroso de Lima, Sérgio Simões, João ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939975/
Jul 05, 2016 · LNPs for RNA delivery: structure and requirements. During the last 5 years, siRNA, microRNA (miRNA) mimetics, antagomirs, and messenger RNA (mRNA) have made tremendous progress as potential therapeutics.7–10 However, targeted delivery and endosome escape still remain the major challenges for RNA drug development.Author: Timofei S Zatsepin, Yuri V Kotelevtsev, Victor Koteliansky
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006671/
Among various nonviral gene vectors, lipid nanoparticles are an ideal platform for the incorporation of safety and efficacy into a single delivery system. In this chapter, we highlight current lipidic vectors that have been developed for gene therapy of tumors and other diseases.Author: Yi Zhao, Leaf Huang
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