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https://link.springer.com/article/10.1007/s11095-006-9180-5
Jan 25, 2007 · Lipid-based colloidal particles have been extensively studied as systemic gene delivery carriers. The topic that we would like to emphasize is the formulation/assembly of lipid-based nanoparticles (NP) with diameter under 100 nm for delivering nucleic acid in vivo. NP are different from cationic lipid–nucleic acid complexes (lipoplexes) and are vesicles composed of lipids and …Author: Weijun Li, Weijun Li, Francis C. Szoka
https://www.ncbi.nlm.nih.gov/pubmed/17252188
Lipid-based colloidal particles have been extensively studied as systemic gene delivery carriers. The topic that we would like to emphasize is the formulation/assembly of lipid-based nanoparticles (NP) with diameter under 100 nm for delivering nucleic acid in vivo.Author: Weijun Li, Weijun Li, Francis C. Szoka
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5006671/
SNALP technology from Tekmira Pharmaceuticals, Inc. is one of the most widely used lipid-based nucleic acid delivery approaches for systemic administration in clinical trials. Lipid vesicles encapsulating nucleic acids are formed instantaneously by mixing lipids dissolved in ethanol with an aqueous solution of nucleic acids in a controlled ...Author: Yi Zhao, Leaf Huang
https://www.researchgate.net/publication/6551888_Lipid-based_Nanoparticles_for_Nucleic_Acid_Delivery
Lipid-based colloidal particles have been extensively studied as systemic gene delivery carriers. The topic that we would like to emphasize is the formulation/assembly of lipid-based nanoparticles ...
https://www.sciencedirect.com/science/article/pii/S0142961214003883
Intracellular protein delivery has potential biotechnological and therapeutic application, but remains technically challenging. In contrast, a plethora of nucleic acid carriers have been developed, with lipid-based nanoparticles (LNPs) among the most clinically advanced reagents for oligonucleotide delivery.Author: Ahmed Atef Eltoukhy, Delai Chen, Omid Veiseh, Jeisa Pelet, Hao Yin, Yizhou Dong, Daniel Griffith And...
https://www.precisionnanosystems.com/areas-of-interest/formulations/lipid-nanoparticles
Lipid nanoparticles (LNPs) are the most clinically advanced non-viral gene delivery system. Lipid nanoparticles safely and effectively deliver nucleic acids, overcoming a major barrier preventing the development and use of genetic medicines. Genetic medicine has many different applications such as gene editing, rapid vaccine development, immuno-oncology and treatment of rare genetic and ...
https://www.sciencedirect.com/science/article/pii/B9780128140338000084
7.2. Solid Lipid Nanoparticles for Peptide and Protein Delivery. Lipid-based nanoparticles are alternative carriers for peptides, proteins, and antigens. The major challenge is optimization of lipid-based carrier systems to incorporate proteins and peptides of a hydrophilic or hydrophobic nature to make them ideal nanocarrier systems .Author: Raj Kumar, Raj Kumar
https://www.cell.com/molecular-therapy-family/nucleic-acids/fulltext/S2162-2531(19)30017-4
mRNA vaccines have the potential to tackle many unmet medical needs that are unable to be addressed with conventional vaccine technologies. A potent and well-tolerated delivery technology is integral to fully realizing the potential of mRNA vaccines. Pre-clinical and clinical studies have demonstrated that mRNA delivered intramuscularly (IM) with first-generation lipid nanoparticles (LNPs ...Author: Kimberly J. Hassett, Kerry E. Benenato, Eric Jacquinet, Aisha Lee, Angela Woods, Olga Yuzhakov, Sunn...
https://pubs.acs.org/doi/10.1021/nl1041947
We report a gold nanoparticle-templated high density lipoprotein (HDL AuNP) platform for gene therapy that combines lipid-based nucleic acid transfection strategies with HDL biomimicry. For proof-of-concept, HDL AuNPs are shown to adsorb antisense cholesterylated DNA. The conjugates are internalized by human cells, can be tracked within cells using transmission electron microscopy, and ...Author: Kaylin M. McMahon, R. Kannan Mutharasan, Sushant Tripathy, Dorina Veliceasa, Mariana Bobeica, Dale K...
https://www.researchgate.net/publication/289691987_Lipid_Nanoparticles_for_the_Delivery_of_Nucleic_Acids
Starting with the ionizable cationic lipid 1,2-dilinoleyloxy-3-dimethylaminopropane (DLinDMA), a key lipid component of stable nucleic acid lipid particles (SNALP) as a benchmark, we used the ...
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