We have collected information about Sirna Delivery By Magnetofection for you. Follow the links to find out details on Sirna Delivery By Magnetofection.
https://www.researchgate.net/publication/23295552_siRNA_delivery_by_magnetofection
Magnetofection is defined as the magnetically enhanced delivery of nucleic acids associated with magnetic nanoparticles and has been utilized to deliver synthetic siRNAs to cultured cells.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571810/
In order to allow an effective intracellular delivery of siRNA, by avoiding degradation, the development of an effective carrier with proper peculiarities is essential. Therefore, a magnetic carrier could be used to carry siRNA inside cells by using magnetofection, that is, by applying a magnetic field to improve nucleic acid cell uptake.
https://www.mdpi.com/2073-4360/11/5/889/htm
Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are recognized as one of the most promising agents for theranostic applications. Among methods designed for siRNA delivery, magnetofection, that is, nucleic acid cell uptake under the influence of a magnetic field acting on magnetic nucleic acid vectors, is emerging as a unique approach to combining advantages such as strong improvement of ...
http://europepmc.org/articles/PMC4321792
Magnetofection is a reliable and gentle alternative method with low cytotoxicity for siRNA delivery into difficult to transfect cells such as mammalian fibroblasts. These features are especially advantageous for functional end point analyses of gene silencing, e.g., on the metabolite level.
https://link.springer.com/protocol/10.1007%2F978-1-60327-547-7_6
Mykhaylyk O., Zelphati O., Hammerschmid E., Anton M., Rosenecker J., Plank C. (2009) Recent Advances in Magnetofection and Its Potential to Deliver siRNAs In Vitro. In: Sioud M. (eds) siRNA and miRNA Gene Silencing. Methods in Molecular Biology (Methods and Protocols), vol 487. Humana Press. First Online 13 October 2008
https://www.physiology.org/doi/10.1152/ajpgi.00233.2017
In these studies, we developed a novel approach of in vivo magnetofection for localized delivery of nucleic acids such as micro-RNA-139-5p (miR-139-5p; which is known to target Rho kinase2) to the circular smooth muscle layer of the internal anal sphincter (IAS).
https://onlinelibrary.wiley.com/doi/full/10.1002/adma.201903637
As a primary nano‐carrier used for siRNA delivery, lipid nanoparticles (to be discussed in the following section) are one of the only systems to have been rigorously studied for quantification and mechanism of cytosolic siRNA delivery. ... 131 Iron oxide‐based systems have also demonstrated unique characteristics, such as magnetofection ...
https://www.hindawi.com/journals/jdd/2012/218940/abs/
Several studies have demonstrated that magnetofection can efficiently deliver siRNA to living cells cultivated in vitro [14–16], and it appears to be a reliable and gentle method for siRNA and DNA delivery into difficult to transfect cells such as mammalian fibroblasts . For magnetofection, polycationic paramagnetic nanoparticles (NPs) are ...
https://pubs.acs.org/doi/abs/10.1021/nn5022567
The present work illustrates unique design, construction and operation of an i-motif-based DNA nanomachine templated on gold nanoparticles (AuNPs), which utilizes pH-responsive dynamic motion of i-motif DNA strands and aggregational behavior of AuNPs to elicit programmed delivery of therapeutic siRNA. The pH-sensitive nucleic acids immobilized on the AuNPs consisted of three functional ...
https://www.prnewswire.com/news-releases/global-transfection-gene-delivery-dna-delivery-protein-delivery-sirna-delivery-technologies-lipofection-calcium-phosphate-electroporation-nucleofection-magnetofection-gene-gun-viral-market-2012---2017-184074851.html
/PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue: Global Transfection (Gene Delivery, DNA Delivery,...
http://www.chemicell.com/products/magnetofection/docs/magnetofection_2_4.pdf
Magnetofection TM the new gene transfection technology Magnetofection TM is a novel, ... 4.7. Magnetofection™ - siRNA 4.7.1. siRNA – PolyMAG Protocol 4.7.2. siRNA – CombiMAG Protocol ... nucleic acid delivery. It is mixed in a one-step procedure with the nucleic acid to be
https://iopscience.iop.org/article/10.1088/1612-2011/13/6/065601
A new method is developed for efficient delivery of short interference RNA into cells using combination of magnetophoresis for pre-concentration of siRNA-magnetic nanoparticle complex on the surface of cells with subsequent nanosecond laser pulse generating stress waves in transfection chamber, which is able to permeabilize cell membrane for the facilitated delivery of siRNA into the cell ...
https://www.prnewswire.com/news-releases/global-transfection-gene-delivery-dna-delivery-protein-delivery-sirna-delivery-technologies-market-2012---2017-213517401.html
Global Transfection (Gene Delivery, DNA Delivery, Protein Delivery, SiRNA Delivery) Technologies Market (2012 - 2017)
https://pubs.acs.org/doi/abs/10.1021/nl304287a
The safe, targeted and effective delivery of gene therapeutics remains a significant barrier to their broad clinical application. Here we develop a magnetic nucleic acid delivery system composed of iron oxide nanoparticles and cationic lipid-like materials termed lipidoids. Coated nanoparticles are capable of delivering DNA and siRNA to cells in culture. The mean hydrodynamic size of these ...
https://www.future-science.com/doi/full/10.4155/tde.11.37
Jul 12, 2011 · Microsphere-mediated delivery of recombinant AAV vectors in vitro and in vivo. Mol. Ther. 1(5),S239 (2000).Crossref, Google Scholar; 2 Plank C, Scherer F, Schillinger U, Anton M. Magnetofection: enhancement and localization of gene delivery with magnetic particles under the influence of a magnetic field. J. Gene Med. 2(5),24 (2000).
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