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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009470/
Topical delivery of 1.5 μM EGFR siRNA incorporated in SNA-NCs to hairless mouse skin almost completely silenced EGFR expression and inhibited downstream MAPK signaling. Although the topical delivery hasn't been applied in miRNA-based therapy yet, we believe it may be a promising delivery system for miRNA-based therapeutic agents in skin cancer.Author: Yunching Chen, Dong Yu Gao, Leaf Huang
https://www.nature.com/articles/s41573-019-0017-4
Mar 07, 2019 · This paper presents a discussion of delivery and endosomal escape challenges. CAS; ... Alvarez-Erviti, L. et al. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes.Author: Ryan L. Setten, Ryan L. Setten, John J. Rossi, John J. Rossi, Si-ping Han, Si-ping Han
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375670/
Jun 25, 2012 · This article reviews the mechanistic principles of RNA interference, its potential, the greatest challenges for use in biomedical applications, and some of the work that has been done toward engineering delivery systems that overcome some of the hurdles facing siRNA-based therapeutics.Author: Gavrilov K, Saltzman Wm
https://www.hindawi.com/journals/jnm/2011/742895/
Small interfering RNAs (siRNAs) technology has emerged as a promising potential treatment for viral, genetic diseases and cancers. Despite the powerful therapeutic potential of siRNA, there are challenges for developing efficient and specific delivery systems for systemic administration. There are extracellular and intracellular barriers for nanoparticle-mediated delivery. First, nanoparticles ...Author: Shutao Guo, Leaf Huang
https://www.researchgate.net/publication/51243923_SiRNA_Delivery_challenges_and_role_of_carrier_systems
Due to these challenges, many strategies are now being developed to deliver the siRNA in such delivery systems that siRNA is protected in both extracellular and intracel- lular environments [22 ...
https://www.nature.com/articles/nmat3765
Oct 23, 2013 · This Review provides an introduction to the biological challenges that siRNA delivery materials aim to overcome, as well as a discussion of the way that the …Author: Rosemary Kanasty, Joseph Robert Dorkin, Arturo Vegas, Arturo Vegas, Daniel Anderson
http://www.eurekaselect.com/144854/article
Conclusion: Delivery of siRNA to the target site is the biggest challenge for its application in the clinic. The findings of this review confirmed by encapsulation siRNA in the nanoparticles can overcome these challenges. The rapid progress in nanotechnology has enabled the development of effective nanoparticles as the carrier for siRNA delivery.Author: Neda Shajari, Behzad Mansoori, Sadaf Davudian, Ali Mohammadi, Behzad Baradaran
https://www.sciencedirect.com/science/article/pii/S0304383516302063
Current siRNA delivery techniques still face obstacles for in vivo gene silencing (), which make it difficult to translate this revolutionary discovery to oncologic clinics.Here we discuss the key concerns raised from recent clinical trials and preclinical studies and explore avenues to develop siRNA cancer therapy to a viable option for oncology care.Author: Tao Wang, Tao Wang, Sarah Shigdar, Hadi Al Shamaileh, Michael P. Gantier, Michael P. Gantier, Wang Y...
https://www.sciencedirect.com/science/article/pii/S2211383513000610
Significant progress has been made in effective delivery of RNAi therapeutics in vivo, although it remains a challenge in this field.This review summarizes the most important parameters that govern the silencing efficiency and duration of the RNAi effect, such as small interfering RNA (siRNA) stability and modification, the type of delivery system and particle sizing methods.Author: Kun Gao, Leaf Huang
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