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https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/self-microemulsifying-drug-delivery-system
Himanshu Agrawal, ... Ambikanandan Misra, in Challenges in Delivery of Therapeutic Genomics and Proteomics, 2011. 11.5.7 Microemulsions. Microemulsions, self-microemulsifying drug delivery systems (SMEEDS), and their parent drug delivery system, that is, emulsions, all come under a single closely related type of drug delivery system, in other words, they are oil-in-water or water-in-oil ...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617838/
Jul 05, 2019 · The purposes of the present study were to: (1) develop a novel solid self-microemulsifying drug delivery system (SMEDDS) formulation of MTX via spray drying with calcium silicate as the solid carrier and (2) evaluate whether the solid SMEDDS improved …Author: Dong Shik Kim, Jung Hyun Cho, Jong Hyuck Park, Jung Suk Kim, Eon Soo Song, Jaewook Kwon, Bhupendra R...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674636/
Feb 06, 2015 · The drug has better antidepressant effect, achieved by acting on the 5-hydroxytryptamine receptor. However, the therapeutic effects of the drug are compromised due to its poor water solubility and lower bioavailability. Herein, a self-microemulsifying drug delivery system (SMEDDS) was developed to improve its solubility and oral bioavailability.Author: Lan Wu, Yanli Qiao, Lina Wang, Jiahua Guo, Guocheng Wang, Wei He, Lifang Yin, Jinhua Zhao
https://pdfs.semanticscholar.org/746a/5a974d3cea1c584e8e80b1ef4a51c952e2a2.pdf
case. The fact that almost 40% of the new drug compounds are hydrophobic in nature implies that studies with SMEDDS will continue, and more drug compounds formulated as SMEDDS will reach the pharmaceutical market in the future. Keywords: Self-microemulsifying drug delivery systems (SMEDDSs), Lipophillic compound, Droplet Size, Oral Bioavailability.
https://www.hindawi.com/journals/isrn/2014/964051/
Ease of administration and painless approach made oral route the most preferred. Poor oral bioavailability is pronounced with the majority of recent active ingredients because of dissolution rate limited absorption. Failure to attain intended therapeutic effect of the poor water soluble drugs by this route led to development of novel drug delivery systems which will fulfill therapeutic needs ...Author: Samatha Akula, Aravind Kumar Gurram, Srinivas Reddy Devireddy
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